TY - JOUR
T1 - A network pharmacology approach to explore the potential role of Panax ginseng on exercise performance
AU - Jisu, Kim
AU - Kang, Pa Lee
AU - Kim, Myoung Ryu
AU - Bom, Sahn Kim
AU - Byung, Seok Moon
AU - Chul, Ho Shin
AU - Suji, Baek
AU - Bok, Sil Hong
N1 - Funding Information:
This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2019S1A5A8033825). This study was supported by the KU Research Professor Program of Konkuk University.
Publisher Copyright:
©2021 Jisu Kim et al. ©2021 The Korean Society for Exercise Nutrition.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - [Purpose] As Panax ginseng C. A. Meyer (ginseng) exhibits various physiological activities and is associated with exercise, we investigated the potential active components of ginseng and related target genes through network pharmacological analysis. Additionally, we analyzed the association between ginseng-related genes, such as the G-protein-coupled receptors (GPCRs), and improved exercise capacity. [Methods] Active compounds in ginseng and the related target genes were searched in the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). Gene ontology functional analysis was performed to identify biological processes related to the collected genes, and a compound-target network was visualized using Cytoscape 3.7.2. [Results] A total of 21 ginseng active compounds were detected, and 110 targets regulated by 17 active substances were identified. We found that the active compound protein was involved in the biological process of adrenergic receptor activity in 80%, G-protein-coupled neurotransmitter in 10%, and leucocyte adhesion to arteries in 10%. Additionally, the biological response centered on adrenergic receptor activity showed a close relationship with G protein through the beta-1 adrenergic receptor gene reactivity. [Conclusion] According to bioavailability analysis, ginseng comprises 21 active compounds. Furthermore, we investigated the ginseng-stimulated gene activation using ontology analysis. GPCR, a gene upregulated by ginseng, is positively correlated to exercise. Therefore, if a study on this factor is conducted, it will provide useful basic data for improving exercise performance and health.
AB - [Purpose] As Panax ginseng C. A. Meyer (ginseng) exhibits various physiological activities and is associated with exercise, we investigated the potential active components of ginseng and related target genes through network pharmacological analysis. Additionally, we analyzed the association between ginseng-related genes, such as the G-protein-coupled receptors (GPCRs), and improved exercise capacity. [Methods] Active compounds in ginseng and the related target genes were searched in the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). Gene ontology functional analysis was performed to identify biological processes related to the collected genes, and a compound-target network was visualized using Cytoscape 3.7.2. [Results] A total of 21 ginseng active compounds were detected, and 110 targets regulated by 17 active substances were identified. We found that the active compound protein was involved in the biological process of adrenergic receptor activity in 80%, G-protein-coupled neurotransmitter in 10%, and leucocyte adhesion to arteries in 10%. Additionally, the biological response centered on adrenergic receptor activity showed a close relationship with G protein through the beta-1 adrenergic receptor gene reactivity. [Conclusion] According to bioavailability analysis, ginseng comprises 21 active compounds. Furthermore, we investigated the ginseng-stimulated gene activation using ontology analysis. GPCR, a gene upregulated by ginseng, is positively correlated to exercise. Therefore, if a study on this factor is conducted, it will provide useful basic data for improving exercise performance and health.
KW - GPCR
KW - Panax ginseng C. A. Meyer
KW - beta-1 adrenergic receptor
KW - exercise
KW - exercise nutrition
KW - traditional Chinese medicine database and analysis platform
UR - http://www.scopus.com/inward/record.url?scp=85123250773&partnerID=8YFLogxK
U2 - 10.20463/pan.2021.0018
DO - 10.20463/pan.2021.0018
M3 - Article
AN - SCOPUS:85123250773
SN - 2733-7545
VL - 25
SP - 28
EP - 35
JO - Physical Activity and Nutrition
JF - Physical Activity and Nutrition
IS - 3
ER -