A network pharmacology approach to explore the potential role of Panax ginseng on exercise performance

Kim Jisu, Pa Lee Kang, Myoung Ryu Kim, Sahn Kim Bom, Seok Moon Byung, Ho Shin Chul, Baek Suji, Sil Hong Bok

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


[Purpose] As Panax ginseng C. A. Meyer (ginseng) exhibits various physiological activities and is associated with exercise, we investigated the potential active components of ginseng and related target genes through network pharmacological analysis. Additionally, we analyzed the association between ginseng-related genes, such as the G-protein-coupled receptors (GPCRs), and improved exercise capacity. [Methods] Active compounds in ginseng and the related target genes were searched in the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). Gene ontology functional analysis was performed to identify biological processes related to the collected genes, and a compound-target network was visualized using Cytoscape 3.7.2. [Results] A total of 21 ginseng active compounds were detected, and 110 targets regulated by 17 active substances were identified. We found that the active compound protein was involved in the biological process of adrenergic receptor activity in 80%, G-protein-coupled neurotransmitter in 10%, and leucocyte adhesion to arteries in 10%. Additionally, the biological response centered on adrenergic receptor activity showed a close relationship with G protein through the beta-1 adrenergic receptor gene reactivity. [Conclusion] According to bioavailability analysis, ginseng comprises 21 active compounds. Furthermore, we investigated the ginseng-stimulated gene activation using ontology analysis. GPCR, a gene upregulated by ginseng, is positively correlated to exercise. Therefore, if a study on this factor is conducted, it will provide useful basic data for improving exercise performance and health.

Original languageEnglish
Pages (from-to)28-35
Number of pages8
JournalPhysical Activity and Nutrition
Issue number3
StatePublished - 1 Sep 2021

Bibliographical note

Funding Information:
This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2019S1A5A8033825). This study was supported by the KU Research Professor Program of Konkuk University.

Publisher Copyright:
©2021 Jisu Kim et al. ©2021 The Korean Society for Exercise Nutrition.


  • GPCR
  • Panax ginseng C. A. Meyer
  • beta-1 adrenergic receptor
  • exercise
  • exercise nutrition
  • traditional Chinese medicine database and analysis platform


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