Abstract
(Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).
| Original language | English |
|---|---|
| Pages (from-to) | 2804-2807 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 47 |
| Issue number | 15 |
| DOIs | |
| State | Published - 31 Mar 2008 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer diagnosis
- Drug screening
- Fluorescent probes
- Gold
- Imaging agents
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