A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency

Jun Chau Chien; Erh Chia Yeh; Luke P. Lee; Mekhail Anwar; Ali M. Niknejad

doi:10.1109/VLSIC.2015.7231312

A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency

Jun Chau Chien, Erh Chia Yeh, Luke P. Lee, Mekhail Anwar, Ali M. Niknejad

Department of Chemistry & Nanoscience

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

7 Scopus citations

Abstract

A near-field modulation chopping technique is implemented in an injection-locked oscillator sensor for the detection of protein conformation changes. With the addition of shielding electrodes, the signal is chopped by electronically switching the paths of the displacement sensing currents while minimizing the up-conversion of the 1/f noise. To maximize the dynamic range, feedback-around-sensor utilizing embedded varactors is applied. A 16-GHz prototype in 65-nm CMOS demonstrates the techniques lower the 1/f corner frequency from 10 to 0.25 kHz while achieving 74.5 dB of dynamic range. Bio-molecular sensing is validated with thermal-cycled bovine serum albumin (BSA) solutions at different conditions.

Original language	English
Title of host publication	2015 Symposium on VLSI Circuits, VLSI Circuits 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	C332-C333
ISBN (Electronic)	9784863485020
DOIs	https://doi.org/10.1109/VLSIC.2015.7231312
State	Published - 31 Aug 2015
Event	29th Annual Symposium on VLSI Circuits, VLSI Circuits 2015 - Kyoto, Japan Duration: 17 Jun 2015 → 19 Jun 2015

Publication series

Name	IEEE Symposium on VLSI Circuits, Digest of Technical Papers
Volume	2015-August

Conference

Conference	29th Annual Symposium on VLSI Circuits, VLSI Circuits 2015
Country/Territory	Japan
City	Kyoto
Period	17/06/15 → 19/06/15

Bibliographical note

Publisher Copyright:
© 2015 JSAP.

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10.1109/VLSIC.2015.7231312

Cite this

Chien, J. C., Yeh, E. C., Lee, L. P., Anwar, M., & Niknejad, A. M. (2015). A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency. In 2015 Symposium on VLSI Circuits, VLSI Circuits 2015 (pp. C332-C333). Article 7231312 (IEEE Symposium on VLSI Circuits, Digest of Technical Papers; Vol. 2015-August). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/VLSIC.2015.7231312

Chien, Jun Chau ; Yeh, Erh Chia ; Lee, Luke P. et al. / A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency. 2015 Symposium on VLSI Circuits, VLSI Circuits 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. C332-C333 (IEEE Symposium on VLSI Circuits, Digest of Technical Papers).

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title = "A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency",

abstract = "A near-field modulation chopping technique is implemented in an injection-locked oscillator sensor for the detection of protein conformation changes. With the addition of shielding electrodes, the signal is chopped by electronically switching the paths of the displacement sensing currents while minimizing the up-conversion of the 1/f noise. To maximize the dynamic range, feedback-around-sensor utilizing embedded varactors is applied. A 16-GHz prototype in 65-nm CMOS demonstrates the techniques lower the 1/f corner frequency from 10 to 0.25 kHz while achieving 74.5 dB of dynamic range. Bio-molecular sensing is validated with thermal-cycled bovine serum albumin (BSA) solutions at different conditions.",

author = "Chien, {Jun Chau} and Yeh, {Erh Chia} and Lee, {Luke P.} and Mekhail Anwar and Niknejad, {Ali M.}",

note = "Publisher Copyright: {\textcopyright} 2015 JSAP.; 29th Annual Symposium on VLSI Circuits, VLSI Circuits 2015 ; Conference date: 17-06-2015 Through 19-06-2015",

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Chien, JC, Yeh, EC, Lee, LP, Anwar, M & Niknejad, AM 2015, A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency. in 2015 Symposium on VLSI Circuits, VLSI Circuits 2015., 7231312, IEEE Symposium on VLSI Circuits, Digest of Technical Papers, vol. 2015-August, Institute of Electrical and Electronics Engineers Inc., pp. C332-C333, 29th Annual Symposium on VLSI Circuits, VLSI Circuits 2015, Kyoto, Japan, 17/06/15. https://doi.org/10.1109/VLSIC.2015.7231312

A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency. / Chien, Jun Chau; Yeh, Erh Chia; Lee, Luke P. et al.
2015 Symposium on VLSI Circuits, VLSI Circuits 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. C332-C333 7231312 (IEEE Symposium on VLSI Circuits, Digest of Technical Papers; Vol. 2015-August).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - A near-field modulation chopping technique is implemented in an injection-locked oscillator sensor for the detection of protein conformation changes. With the addition of shielding electrodes, the signal is chopped by electronically switching the paths of the displacement sensing currents while minimizing the up-conversion of the 1/f noise. To maximize the dynamic range, feedback-around-sensor utilizing embedded varactors is applied. A 16-GHz prototype in 65-nm CMOS demonstrates the techniques lower the 1/f corner frequency from 10 to 0.25 kHz while achieving 74.5 dB of dynamic range. Bio-molecular sensing is validated with thermal-cycled bovine serum albumin (BSA) solutions at different conditions.

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Chien JC, Yeh EC, Lee LP, Anwar M, Niknejad AM. A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency. In 2015 Symposium on VLSI Circuits, VLSI Circuits 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. C332-C333. 7231312. (IEEE Symposium on VLSI Circuits, Digest of Technical Papers). doi: 10.1109/VLSIC.2015.7231312

A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency

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