A Nanostructured Phthalocyanine/Albumin Supramolecular Assembly for Fluorescence Turn-On Imaging and Photodynamic Immunotherapy

Rui Wang, Kyu Hwan Kim, Jiyoon Yoo, Xingshu Li, Nahyun Kwon, Yun Hui Jeon, Suk Kyung Shin, Seung Seok Han, Dong Sup Lee, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Smart phototheranostic nanomaterials are of significant interest for high-quality imaging and targeted therapy in the precision medicine field. Herein, a nanoscale photosensitizer (NanoPcM) is constructed through the self-assembly of morpholine-substituted silicon phthalocyanine (PcM) and albumin. NanoPcM displays a turn-on fluorescence depending on the acid-induced abolition of the photoinduced electron transfer effect (change in molecular structure) and disassembly of the nanostructure (change in supramolecular structure), which enables low-background and tumor-targeted fluorescence imaging. In addition, its efficient type I photoreaction endows NanoPcM with a superior immunogenic photodynamic therapy (PDT) effect against solid tumors. The combination of NanoPcM-based PDT and αPD-1-based immunotherapy can efficiently inhibit tumor growth, reduce spontaneous lung metastasis, and trigger abscopal effects. This study should provide a perspective for the future design of nanomaterials as promising phototheranostics for cancer imaging and therapy.

Original languageEnglish
Pages (from-to)3045-3058
Number of pages14
JournalACS Nano
Volume16
Issue number2
DOIs
StatePublished - 22 Feb 2022

Keywords

  • photodynamic immunotherapy
  • phototheranostic
  • phthalocyanine
  • supramolecular assembly
  • turn-on fluorescence

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