Smart phototheranostic nanomaterials are of significant interest for high-quality imaging and targeted therapy in the precision medicine field. Herein, a nanoscale photosensitizer (NanoPcM) is constructed through the self-assembly of morpholine-substituted silicon phthalocyanine (PcM) and albumin. NanoPcM displays a turn-on fluorescence depending on the acid-induced abolition of the photoinduced electron transfer effect (change in molecular structure) and disassembly of the nanostructure (change in supramolecular structure), which enables low-background and tumor-targeted fluorescence imaging. In addition, its efficient type I photoreaction endows NanoPcM with a superior immunogenic photodynamic therapy (PDT) effect against solid tumors. The combination of NanoPcM-based PDT and αPD-1-based immunotherapy can efficiently inhibit tumor growth, reduce spontaneous lung metastasis, and trigger abscopal effects. This study should provide a perspective for the future design of nanomaterials as promising phototheranostics for cancer imaging and therapy.
Bibliographical noteFunding Information:
X.L. thanks the National Natural Science Foundation of China (Grant No. 22078066). D.-S.L. thanks the Basic Research Program (NRF-2021R1A2C1011920) of the National Research Foundation of Korea (NRF), which is funded by the Korean Government (Ministry of Science & ICT). J.Y. thanks the NRF, which is funded by the Korean government (MSIP) (No. 2012R1A3A2048814) and the Ministry of Education (2021R1A6A1A10039823).
© 2022 American Chemical Society
- photodynamic immunotherapy
- supramolecular assembly
- turn-on fluorescence