A Multimodal Multichannel Neural Activity Readout IC with 0.7μW/Channel Ca2+-Probe-Based Fluorescence Recording and Electrical Recording

Taeju Lee, Jee Ho Park, Ji Hyoung Cha, Namsun Chou, Doojin Jang, Ji Hoon Kim, Il Joo Cho, Seong Jin Kim, Minkyu Je

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations

Abstract

This paper presents a multimodal multichannel neural activity readout IC which can perform not only the electrical recording (ER) but also the fluorescence recording (FR) of neural activity for the cell-type-specific study of heterogeneous neuronal cell populations. The time-based FR circuit senses Ca2+ concentration using Ca2+ probes while the ER circuit acquires action potentials (APs) and local field potentials (LFPs). The IC is fabricated in 0.18μm CMOS. The FR circuit achieves a recording range of 81dB (75pA to 860nA) and consumes the power of 0.7μmW/Ch. The ER circuit achieves the input-referred noise (IRN) of 2.7μm Vrms over the bandwidth (BW) of 10kHz, while consuming the power of 4.9μmW/Ch. The in-vitro measurement is performed for recording Ca2+ concentration and electrical neural signals.

Original languageEnglish
Title of host publication2019 Symposium on VLSI Circuits, VLSI Circuits 2019 - Digest of Technical Papers
PublisherInstitute of Electrical and Electronics Engineers Inc.
PagesC290-C291
ISBN (Electronic)9784863487185
DOIs
StatePublished - Jun 2019
Event33rd Symposium on VLSI Circuits, VLSI Circuits 2019 - Kyoto, Japan
Duration: 9 Jun 201914 Jun 2019

Publication series

NameIEEE Symposium on VLSI Circuits, Digest of Technical Papers
Volume2019-June

Conference

Conference33rd Symposium on VLSI Circuits, VLSI Circuits 2019
Country/TerritoryJapan
CityKyoto
Period9/06/1914/06/19

Keywords

  • calcium ion sensing
  • electrical recording
  • fluorescence recording
  • Neural activity readout IC
  • time-based operation

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