This paper presents a multimodal multichannel neural activity readout IC which can perform not only the electrical recording (ER) but also the fluorescence recording (FR) of neural activity for the cell-type-specific study of heterogeneous neuronal cell populations. The time-based FR circuit senses Ca2+ concentration using Ca2+ probes while the ER circuit acquires action potentials (APs) and local field potentials (LFPs). The IC is fabricated in 0.18μm CMOS. The FR circuit achieves a recording range of 81dB (75pA to 860nA) and consumes the power of 0.7μmW/Ch. The ER circuit achieves the input-referred noise (IRN) of 2.7μm Vrms over the bandwidth (BW) of 10kHz, while consuming the power of 4.9μmW/Ch. The in-vitro measurement is performed for recording Ca2+ concentration and electrical neural signals.
|Title of host publication||2019 Symposium on VLSI Circuits, VLSI Circuits 2019 - Digest of Technical Papers|
|Publisher||Institute of Electrical and Electronics Engineers Inc.|
|State||Published - Jun 2019|
|Event||33rd Symposium on VLSI Circuits, VLSI Circuits 2019 - Kyoto, Japan|
Duration: 9 Jun 2019 → 14 Jun 2019
|Name||IEEE Symposium on VLSI Circuits, Digest of Technical Papers|
|Conference||33rd Symposium on VLSI Circuits, VLSI Circuits 2019|
|Period||9/06/19 → 14/06/19|
Bibliographical noteFunding Information:
This research was supported by the Convergence Technology Development Program for Bionic Arm (2017M3C1B2085296) and the Brain Research Program (2017M3C7A1028859) through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT.
© 2019 JSAP.
- calcium ion sensing
- electrical recording
- fluorescence recording
- Neural activity readout IC
- time-based operation