A Multimodal Multichannel Neural Activity Readout IC with 0.7μW/Channel Ca2+-Probe-Based Fluorescence Recording and Electrical Recording

Taeju Lee; Jee Ho Park; Ji Hyoung Cha; Namsun Chou; Doojin Jang; Ji Hoon Kim; Il Joo Cho; Seong Jin Kim; Minkyu Je

doi:10.23919/VLSIC.2019.8778042

A Multimodal Multichannel Neural Activity Readout IC with 0.7μW/Channel Ca²⁺-Probe-Based Fluorescence Recording and Electrical Recording

Taeju Lee, Jee Ho Park, Ji Hyoung Cha, Namsun Chou, Doojin Jang, Ji Hoon Kim, Il Joo Cho, Seong Jin Kim, Minkyu Je

Electronic and Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

8 Scopus citations

Abstract

This paper presents a multimodal multichannel neural activity readout IC which can perform not only the electrical recording (ER) but also the fluorescence recording (FR) of neural activity for the cell-type-specific study of heterogeneous neuronal cell populations. The time-based FR circuit senses Ca²⁺ concentration using Ca²⁺ probes while the ER circuit acquires action potentials (APs) and local field potentials (LFPs). The IC is fabricated in 0.18μm CMOS. The FR circuit achieves a recording range of 81dB (75pA to 860nA) and consumes the power of 0.7μmW/Ch. The ER circuit achieves the input-referred noise (IRN) of 2.7μm V_rms over the bandwidth (BW) of 10kHz, while consuming the power of 4.9μmW/Ch. The in-vitro measurement is performed for recording Ca²⁺ concentration and electrical neural signals.

Original language	English
Title of host publication	2019 Symposium on VLSI Circuits, VLSI Circuits 2019 - Digest of Technical Papers
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	C290-C291
ISBN (Electronic)	9784863487185
DOIs	https://doi.org/10.23919/VLSIC.2019.8778042
State	Published - Jun 2019
Event	33rd Symposium on VLSI Circuits, VLSI Circuits 2019 - Kyoto, Japan Duration: 9 Jun 2019 → 14 Jun 2019

Publication series

Name	IEEE Symposium on VLSI Circuits, Digest of Technical Papers
Volume	2019-June

Conference

Conference	33rd Symposium on VLSI Circuits, VLSI Circuits 2019
Country/Territory	Japan
City	Kyoto
Period	9/06/19 → 14/06/19

Keywords

calcium ion sensing
electrical recording
fluorescence recording
Neural activity readout IC
time-based operation

Access to Document

10.23919/VLSIC.2019.8778042

Cite this

Lee, T., Park, J. H., Cha, J. H., Chou, N., Jang, D., Kim, J. H., Cho, I. J., Kim, S. J., & Je, M. (2019). A Multimodal Multichannel Neural Activity Readout IC with 0.7μW/Channel Ca²⁺-Probe-Based Fluorescence Recording and Electrical Recording. In 2019 Symposium on VLSI Circuits, VLSI Circuits 2019 - Digest of Technical Papers (pp. C290-C291). [8778042] (IEEE Symposium on VLSI Circuits, Digest of Technical Papers; Vol. 2019-June). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.23919/VLSIC.2019.8778042

Lee, Taeju ; Park, Jee Ho ; Cha, Ji Hyoung et al. / A Multimodal Multichannel Neural Activity Readout IC with 0.7μW/Channel Ca²⁺-Probe-Based Fluorescence Recording and Electrical Recording. 2019 Symposium on VLSI Circuits, VLSI Circuits 2019 - Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc., 2019. pp. C290-C291 (IEEE Symposium on VLSI Circuits, Digest of Technical Papers).

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title = "A Multimodal Multichannel Neural Activity Readout IC with 0.7μW/Channel Ca2+-Probe-Based Fluorescence Recording and Electrical Recording",

abstract = "This paper presents a multimodal multichannel neural activity readout IC which can perform not only the electrical recording (ER) but also the fluorescence recording (FR) of neural activity for the cell-type-specific study of heterogeneous neuronal cell populations. The time-based FR circuit senses Ca2+ concentration using Ca2+ probes while the ER circuit acquires action potentials (APs) and local field potentials (LFPs). The IC is fabricated in 0.18μm CMOS. The FR circuit achieves a recording range of 81dB (75pA to 860nA) and consumes the power of 0.7μmW/Ch. The ER circuit achieves the input-referred noise (IRN) of 2.7μm Vrms over the bandwidth (BW) of 10kHz, while consuming the power of 4.9μmW/Ch. The in-vitro measurement is performed for recording Ca2+ concentration and electrical neural signals.",

keywords = "calcium ion sensing, electrical recording, fluorescence recording, Neural activity readout IC, time-based operation",

author = "Taeju Lee and Park, {Jee Ho} and Cha, {Ji Hyoung} and Namsun Chou and Doojin Jang and Kim, {Ji Hoon} and Cho, {Il Joo} and Kim, {Seong Jin} and Minkyu Je",

note = "Funding Information: This research was supported by the Convergence Technology Development Program for Bionic Arm (2017M3C1B2085296) and the Brain Research Program (2017M3C7A1028859) through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT. Publisher Copyright: {\textcopyright} 2019 JSAP.; null ; Conference date: 09-06-2019 Through 14-06-2019",

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doi = "10.23919/VLSIC.2019.8778042",

language = "English",

series = "IEEE Symposium on VLSI Circuits, Digest of Technical Papers",

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Lee, T, Park, JH, Cha, JH, Chou, N, Jang, D, Kim, JH, Cho, IJ, Kim, SJ & Je, M 2019, A Multimodal Multichannel Neural Activity Readout IC with 0.7μW/Channel Ca²⁺-Probe-Based Fluorescence Recording and Electrical Recording. in 2019 Symposium on VLSI Circuits, VLSI Circuits 2019 - Digest of Technical Papers., 8778042, IEEE Symposium on VLSI Circuits, Digest of Technical Papers, vol. 2019-June, Institute of Electrical and Electronics Engineers Inc., pp. C290-C291, 33rd Symposium on VLSI Circuits, VLSI Circuits 2019, Kyoto, Japan, 9/06/19. https://doi.org/10.23919/VLSIC.2019.8778042

A Multimodal Multichannel Neural Activity Readout IC with 0.7μW/Channel Ca²⁺-Probe-Based Fluorescence Recording and Electrical Recording. / Lee, Taeju; Park, Jee Ho; Cha, Ji Hyoung et al.

2019 Symposium on VLSI Circuits, VLSI Circuits 2019 - Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc., 2019. p. C290-C291 8778042 (IEEE Symposium on VLSI Circuits, Digest of Technical Papers; Vol. 2019-June).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Park, Jee Ho

AU - Cha, Ji Hyoung

AU - Chou, Namsun

AU - Jang, Doojin

AU - Kim, Ji Hoon

AU - Cho, Il Joo

AU - Kim, Seong Jin

AU - Je, Minkyu

N1 - Funding Information: This research was supported by the Convergence Technology Development Program for Bionic Arm (2017M3C1B2085296) and the Brain Research Program (2017M3C7A1028859) through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT. Publisher Copyright: © 2019 JSAP.

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N2 - This paper presents a multimodal multichannel neural activity readout IC which can perform not only the electrical recording (ER) but also the fluorescence recording (FR) of neural activity for the cell-type-specific study of heterogeneous neuronal cell populations. The time-based FR circuit senses Ca2+ concentration using Ca2+ probes while the ER circuit acquires action potentials (APs) and local field potentials (LFPs). The IC is fabricated in 0.18μm CMOS. The FR circuit achieves a recording range of 81dB (75pA to 860nA) and consumes the power of 0.7μmW/Ch. The ER circuit achieves the input-referred noise (IRN) of 2.7μm Vrms over the bandwidth (BW) of 10kHz, while consuming the power of 4.9μmW/Ch. The in-vitro measurement is performed for recording Ca2+ concentration and electrical neural signals.

AB - This paper presents a multimodal multichannel neural activity readout IC which can perform not only the electrical recording (ER) but also the fluorescence recording (FR) of neural activity for the cell-type-specific study of heterogeneous neuronal cell populations. The time-based FR circuit senses Ca2+ concentration using Ca2+ probes while the ER circuit acquires action potentials (APs) and local field potentials (LFPs). The IC is fabricated in 0.18μm CMOS. The FR circuit achieves a recording range of 81dB (75pA to 860nA) and consumes the power of 0.7μmW/Ch. The ER circuit achieves the input-referred noise (IRN) of 2.7μm Vrms over the bandwidth (BW) of 10kHz, while consuming the power of 4.9μmW/Ch. The in-vitro measurement is performed for recording Ca2+ concentration and electrical neural signals.

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KW - fluorescence recording

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KW - time-based operation

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U2 - 10.23919/VLSIC.2019.8778042

DO - 10.23919/VLSIC.2019.8778042

M3 - Conference contribution

AN - SCOPUS:85073899513

T3 - IEEE Symposium on VLSI Circuits, Digest of Technical Papers

SP - C290-C291

BT - 2019 Symposium on VLSI Circuits, VLSI Circuits 2019 - Digest of Technical Papers

PB - Institute of Electrical and Electronics Engineers Inc.

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Lee T, Park JH, Cha JH, Chou N, Jang D, Kim JH et al. A Multimodal Multichannel Neural Activity Readout IC with 0.7μW/Channel Ca²⁺-Probe-Based Fluorescence Recording and Electrical Recording. In 2019 Symposium on VLSI Circuits, VLSI Circuits 2019 - Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc. 2019. p. C290-C291. 8778042. (IEEE Symposium on VLSI Circuits, Digest of Technical Papers). doi: 10.23919/VLSIC.2019.8778042