A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response

Casey McQuade; Ajlan Al Zaki; Yaanik Desai; Michael Vido; Timothy Sakhuja; Zhiliang Cheng; Andrew Tsourkas; Robert J. Hickey; Daniel Joh; Gary Kao; Jay F. Dorsey; So Jung Park

doi:10.1002/smll.201401927

A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response

Casey McQuade, Ajlan Al Zaki, Yaanik Desai, Michael Vido, Timothy Sakhuja, Zhiliang Cheng, Andrew Tsourkas, Robert J. Hickey, Daniel Joh, Gary Kao, Jay F. Dorsey, So Jung Park

Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Gold nanoparticles have garnered interest as both radiosensitzers and computed tomography (CT) contrast agents. However, the extremely high concentrations of gold required to generate CT contrast is far beyond that needed for meaningful radiosensitization, which limits their use as combined therapeutic-diagnostic (theranostic) agents. To establish a theranostic nanoplatform with well-aligned radiotherapeutic and diagnostic properties for better integration into standard radiation therapy practice, a gold- and superparamagnetic iron oxide nanoparticle (SPION)-loaded micelle (GSM) is developed. Intravenous injection of GSMs into tumor-bearing mice led to selective tumoral accumulation, enabling magnetic resonance (MR) imaging of tumor margins. Subsequent irradiation leads to a 90-day survival of 71% in GSM-treated mice, compared with 25% for irradiation-only mice. Furthermore, measurements of the GSM-enhanced MR contrast are highly predictive of tumor response. Therefore, GSMs may not only guide and enhance the efficacy of radiation therapy, but may allow patients to be managed more effectively.

Original language	English
Pages (from-to)	834-843
Number of pages	10
Journal	Small
Volume	11
Issue number	7
DOIs	https://doi.org/10.1002/smll.201401927
State	Published - 18 Feb 2015

Bibliographical note

Funding Information:
C. McQuade and A. Al Zaki contributed equally to this work. The authors gratefully acknowledge Dr. Cameron Koch, Walter T. Jenkins, and Lee Shuman for insightful discussions and technical support with the SARRP, Dewight Williams for assistance with the TEM, and David Vann for help with ICP‐OES. This work was supported by NIH/NINDS (RC1 CA145075 and K08 NS076548, JD), NIH/NIBIB (R21 EB013754 and R01 EB012065, AT), NIH/NCI (R01 CA157766, AT; R01 CA175480, ZC; R01 CA181429; JD and AT) and the Burroughs Wellcome Career Award for Medical Scientists (1006792; JD).

Publisher Copyright:
© 2014 Wiley-VCH Verlag GmbH & Co. KGaA.

Keywords

Gold
Iron oxide
Magnetic resonance
Nanoparticles
Radiation therapy

Access to Document

10.1002/smll.201401927

Cite this

@article{7e623d467b044b4b86918a4659c8d1eb,

title = "A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response",

abstract = "Gold nanoparticles have garnered interest as both radiosensitzers and computed tomography (CT) contrast agents. However, the extremely high concentrations of gold required to generate CT contrast is far beyond that needed for meaningful radiosensitization, which limits their use as combined therapeutic-diagnostic (theranostic) agents. To establish a theranostic nanoplatform with well-aligned radiotherapeutic and diagnostic properties for better integration into standard radiation therapy practice, a gold- and superparamagnetic iron oxide nanoparticle (SPION)-loaded micelle (GSM) is developed. Intravenous injection of GSMs into tumor-bearing mice led to selective tumoral accumulation, enabling magnetic resonance (MR) imaging of tumor margins. Subsequent irradiation leads to a 90-day survival of 71% in GSM-treated mice, compared with 25% for irradiation-only mice. Furthermore, measurements of the GSM-enhanced MR contrast are highly predictive of tumor response. Therefore, GSMs may not only guide and enhance the efficacy of radiation therapy, but may allow patients to be managed more effectively.",

keywords = "Gold, Iron oxide, Magnetic resonance, Nanoparticles, Radiation therapy",

author = "Casey McQuade and {Al Zaki}, Ajlan and Yaanik Desai and Michael Vido and Timothy Sakhuja and Zhiliang Cheng and Andrew Tsourkas and Hickey, {Robert J.} and Daniel Joh and Gary Kao and Dorsey, {Jay F.} and Park, {So Jung}",

note = "Funding Information: C. McQuade and A. Al Zaki contributed equally to this work. The authors gratefully acknowledge Dr. Cameron Koch, Walter T. Jenkins, and Lee Shuman for insightful discussions and technical support with the SARRP, Dewight Williams for assistance with the TEM, and David Vann for help with ICP‐OES. This work was supported by NIH/NINDS (RC1 CA145075 and K08 NS076548, JD), NIH/NIBIB (R21 EB013754 and R01 EB012065, AT), NIH/NCI (R01 CA157766, AT; R01 CA175480, ZC; R01 CA181429; JD and AT) and the Burroughs Wellcome Career Award for Medical Scientists (1006792; JD). Publisher Copyright: {\textcopyright} 2014 Wiley-VCH Verlag GmbH & Co. KGaA.",

year = "2015",

month = feb,

day = "18",

doi = "10.1002/smll.201401927",

language = "English",

volume = "11",

pages = "834--843",

journal = "Small",

issn = "1613-6810",

publisher = "Wiley-VCH Verlag",

number = "7",

}

TY - JOUR

T1 - A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response

AU - McQuade, Casey

AU - Al Zaki, Ajlan

AU - Desai, Yaanik

AU - Vido, Michael

AU - Sakhuja, Timothy

AU - Cheng, Zhiliang

AU - Tsourkas, Andrew

AU - Hickey, Robert J.

AU - Joh, Daniel

AU - Kao, Gary

AU - Dorsey, Jay F.

AU - Park, So Jung

N1 - Funding Information: C. McQuade and A. Al Zaki contributed equally to this work. The authors gratefully acknowledge Dr. Cameron Koch, Walter T. Jenkins, and Lee Shuman for insightful discussions and technical support with the SARRP, Dewight Williams for assistance with the TEM, and David Vann for help with ICP‐OES. This work was supported by NIH/NINDS (RC1 CA145075 and K08 NS076548, JD), NIH/NIBIB (R21 EB013754 and R01 EB012065, AT), NIH/NCI (R01 CA157766, AT; R01 CA175480, ZC; R01 CA181429; JD and AT) and the Burroughs Wellcome Career Award for Medical Scientists (1006792; JD). Publisher Copyright: © 2014 Wiley-VCH Verlag GmbH & Co. KGaA.

PY - 2015/2/18

Y1 - 2015/2/18

N2 - Gold nanoparticles have garnered interest as both radiosensitzers and computed tomography (CT) contrast agents. However, the extremely high concentrations of gold required to generate CT contrast is far beyond that needed for meaningful radiosensitization, which limits their use as combined therapeutic-diagnostic (theranostic) agents. To establish a theranostic nanoplatform with well-aligned radiotherapeutic and diagnostic properties for better integration into standard radiation therapy practice, a gold- and superparamagnetic iron oxide nanoparticle (SPION)-loaded micelle (GSM) is developed. Intravenous injection of GSMs into tumor-bearing mice led to selective tumoral accumulation, enabling magnetic resonance (MR) imaging of tumor margins. Subsequent irradiation leads to a 90-day survival of 71% in GSM-treated mice, compared with 25% for irradiation-only mice. Furthermore, measurements of the GSM-enhanced MR contrast are highly predictive of tumor response. Therefore, GSMs may not only guide and enhance the efficacy of radiation therapy, but may allow patients to be managed more effectively.

AB - Gold nanoparticles have garnered interest as both radiosensitzers and computed tomography (CT) contrast agents. However, the extremely high concentrations of gold required to generate CT contrast is far beyond that needed for meaningful radiosensitization, which limits their use as combined therapeutic-diagnostic (theranostic) agents. To establish a theranostic nanoplatform with well-aligned radiotherapeutic and diagnostic properties for better integration into standard radiation therapy practice, a gold- and superparamagnetic iron oxide nanoparticle (SPION)-loaded micelle (GSM) is developed. Intravenous injection of GSMs into tumor-bearing mice led to selective tumoral accumulation, enabling magnetic resonance (MR) imaging of tumor margins. Subsequent irradiation leads to a 90-day survival of 71% in GSM-treated mice, compared with 25% for irradiation-only mice. Furthermore, measurements of the GSM-enhanced MR contrast are highly predictive of tumor response. Therefore, GSMs may not only guide and enhance the efficacy of radiation therapy, but may allow patients to be managed more effectively.

KW - Gold

KW - Iron oxide

KW - Magnetic resonance

KW - Nanoparticles

KW - Radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=84923013303&partnerID=8YFLogxK

U2 - 10.1002/smll.201401927

DO - 10.1002/smll.201401927

M3 - Article

C2 - 25264301

AN - SCOPUS:84923013303

SN - 1613-6810

VL - 11

SP - 834

EP - 843

JO - Small

JF - Small

IS - 7

ER -

A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this