A Mononuclear Nonheme Iron(IV)-Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450

Xiaoyan Lu; Xiao Xi Li; Mi Sook Seo; Yong Min Lee; Martin Clémancey; Pascale Maldivi; Jean Marc Latour; Ritimukta Sarangi; Shunichi Fukuzumi; Wonwoo Nam

doi:10.1021/jacs.8b11045

A Mononuclear Nonheme Iron(IV)-Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450

Xiaoyan Lu
, Xiao Xi Li
, Mi Sook Seo
, Yong Min Lee
, Martin Clémancey
, Pascale Maldivi
, Jean Marc Latour
, Ritimukta Sarangi
, Shunichi Fukuzumi
, Wonwoo Nam

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A mononuclear nonheme iron(IV)-amido complex bearing a tetraamido macrocyclic ligand, [(TAML)Fe ^IV (NHTs)] ^- (1), was synthesized via a hydrogen atom (H atom) abstraction reaction of an iron(V)-imido complex, [(TAML)Fe ^V (NTs)] ^- (2), and fully characterized using various spectroscopies. We then investigated (1) the pK _a of 1, (2) the reaction of 1 with a carbon-centered radical, and (3) the H atom abstraction reaction of 1. To the best of our knowledge, the present study reports for the first time the synthesis and chemical properties/reactions of a high-valent iron(IV)-amido complex.

Original language	English
Pages (from-to)	80-83
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	141
Issue number	1
DOIs	https://doi.org/10.1021/jacs.8b11045
State	Published - 9 Jan 2019

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.

Access to Document

10.1021/jacs.8b11045

Cite this

@article{0845a0cc77d14156b73ee29c6183a52d,

title = "A Mononuclear Nonheme Iron(IV)-Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450",

abstract = " A mononuclear nonheme iron(IV)-amido complex bearing a tetraamido macrocyclic ligand, [(TAML)Fe IV (NHTs)] - (1), was synthesized via a hydrogen atom (H atom) abstraction reaction of an iron(V)-imido complex, [(TAML)Fe V (NTs)] - (2), and fully characterized using various spectroscopies. We then investigated (1) the pK a of 1, (2) the reaction of 1 with a carbon-centered radical, and (3) the H atom abstraction reaction of 1. To the best of our knowledge, the present study reports for the first time the synthesis and chemical properties/reactions of a high-valent iron(IV)-amido complex.",

author = "Xiaoyan Lu and Li, \{Xiao Xi\} and Seo, \{Mi Sook\} and Lee, \{Yong Min\} and Martin Cl{\'e}mancey and Pascale Maldivi and Latour, \{Jean Marc\} and Ritimukta Sarangi and Shunichi Fukuzumi and Wonwoo Nam",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2019",

month = jan,

day = "9",

doi = "10.1021/jacs.8b11045",

language = "English",

volume = "141",

pages = "80--83",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - A Mononuclear Nonheme Iron(IV)-Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450

AU - Lu, Xiaoyan

AU - Li, Xiao Xi

AU - Seo, Mi Sook

AU - Lee, Yong Min

AU - Clémancey, Martin

AU - Maldivi, Pascale

AU - Latour, Jean Marc

AU - Sarangi, Ritimukta

AU - Fukuzumi, Shunichi

AU - Nam, Wonwoo

PY - 2019/1/9

Y1 - 2019/1/9

N2 - A mononuclear nonheme iron(IV)-amido complex bearing a tetraamido macrocyclic ligand, [(TAML)Fe IV (NHTs)] - (1), was synthesized via a hydrogen atom (H atom) abstraction reaction of an iron(V)-imido complex, [(TAML)Fe V (NTs)] - (2), and fully characterized using various spectroscopies. We then investigated (1) the pK a of 1, (2) the reaction of 1 with a carbon-centered radical, and (3) the H atom abstraction reaction of 1. To the best of our knowledge, the present study reports for the first time the synthesis and chemical properties/reactions of a high-valent iron(IV)-amido complex.

AB - A mononuclear nonheme iron(IV)-amido complex bearing a tetraamido macrocyclic ligand, [(TAML)Fe IV (NHTs)] - (1), was synthesized via a hydrogen atom (H atom) abstraction reaction of an iron(V)-imido complex, [(TAML)Fe V (NTs)] - (2), and fully characterized using various spectroscopies. We then investigated (1) the pK a of 1, (2) the reaction of 1 with a carbon-centered radical, and (3) the H atom abstraction reaction of 1. To the best of our knowledge, the present study reports for the first time the synthesis and chemical properties/reactions of a high-valent iron(IV)-amido complex.

UR - https://www.scopus.com/pages/publications/85059848067

U2 - 10.1021/jacs.8b11045

DO - 10.1021/jacs.8b11045

M3 - Article

C2 - 30558411

AN - SCOPUS:85059848067

SN - 0002-7863

VL - 141

SP - 80

EP - 83

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 1

ER -

A Mononuclear Nonheme Iron(IV)-Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this