A Mononuclear Nonheme Iron(IV)-Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450

Xiaoyan Lu, Xiao Xi Li, Mi Sook Seo, Yong Min Lee, Martin Clémancey, Pascale Maldivi, Jean Marc Latour, Ritimukta Sarangi, Shunichi Fukuzumi, Wonwoo Nam

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16 Scopus citations

Abstract

A mononuclear nonheme iron(IV)-amido complex bearing a tetraamido macrocyclic ligand, [(TAML)Fe IV (NHTs)] - (1), was synthesized via a hydrogen atom (H atom) abstraction reaction of an iron(V)-imido complex, [(TAML)Fe V (NTs)] - (2), and fully characterized using various spectroscopies. We then investigated (1) the pK a of 1, (2) the reaction of 1 with a carbon-centered radical, and (3) the H atom abstraction reaction of 1. To the best of our knowledge, the present study reports for the first time the synthesis and chemical properties/reactions of a high-valent iron(IV)-amido complex.

Original languageEnglish
Pages (from-to)80-83
Number of pages4
JournalJournal of the American Chemical Society
Volume141
Issue number1
DOIs
StatePublished - 9 Jan 2019

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