A Mononuclear Nonheme Iron(IV)-Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450

Xiaoyan Lu; Xiao Xi Li; Mi Sook Seo; Yong Min Lee; Martin Clémancey; Pascale Maldivi; Jean Marc Latour; Ritimukta Sarangi; Shunichi Fukuzumi; Wonwoo Nam

doi:10.1021/jacs.8b11045

A Mononuclear Nonheme Iron(IV)-Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450

Xiaoyan Lu, Xiao Xi Li, Mi Sook Seo, Yong Min Lee, Martin Clémancey, Pascale Maldivi, Jean Marc Latour, Ritimukta Sarangi, Shunichi Fukuzumi, Wonwoo Nam

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A mononuclear nonheme iron(IV)-amido complex bearing a tetraamido macrocyclic ligand, [(TAML)Fe ^IV (NHTs)] ^- (1), was synthesized via a hydrogen atom (H atom) abstraction reaction of an iron(V)-imido complex, [(TAML)Fe ^V (NTs)] ^- (2), and fully characterized using various spectroscopies. We then investigated (1) the pK _a of 1, (2) the reaction of 1 with a carbon-centered radical, and (3) the H atom abstraction reaction of 1. To the best of our knowledge, the present study reports for the first time the synthesis and chemical properties/reactions of a high-valent iron(IV)-amido complex.

Original language	English
Pages (from-to)	80-83
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	141
Issue number	1
DOIs	https://doi.org/10.1021/jacs.8b11045
State	Published - 9 Jan 2019

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© 2018 American Chemical Society.

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title = "A Mononuclear Nonheme Iron(IV)-Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450",

abstract = " A mononuclear nonheme iron(IV)-amido complex bearing a tetraamido macrocyclic ligand, [(TAML)Fe IV (NHTs)] - (1), was synthesized via a hydrogen atom (H atom) abstraction reaction of an iron(V)-imido complex, [(TAML)Fe V (NTs)] - (2), and fully characterized using various spectroscopies. We then investigated (1) the pK a of 1, (2) the reaction of 1 with a carbon-centered radical, and (3) the H atom abstraction reaction of 1. To the best of our knowledge, the present study reports for the first time the synthesis and chemical properties/reactions of a high-valent iron(IV)-amido complex.",

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AU - Lu, Xiaoyan

AU - Li, Xiao Xi

AU - Seo, Mi Sook

AU - Lee, Yong Min

AU - Clémancey, Martin

AU - Maldivi, Pascale

AU - Latour, Jean Marc

AU - Sarangi, Ritimukta

AU - Fukuzumi, Shunichi

AU - Nam, Wonwoo

PY - 2019/1/9

Y1 - 2019/1/9

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AB - A mononuclear nonheme iron(IV)-amido complex bearing a tetraamido macrocyclic ligand, [(TAML)Fe IV (NHTs)] - (1), was synthesized via a hydrogen atom (H atom) abstraction reaction of an iron(V)-imido complex, [(TAML)Fe V (NTs)] - (2), and fully characterized using various spectroscopies. We then investigated (1) the pK a of 1, (2) the reaction of 1 with a carbon-centered radical, and (3) the H atom abstraction reaction of 1. To the best of our knowledge, the present study reports for the first time the synthesis and chemical properties/reactions of a high-valent iron(IV)-amido complex.

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A Mononuclear Nonheme Iron(IV)-Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450

Abstract

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