@inproceedings{28dad4ff47c14c258fab63956493f7c5,
title = "A microfluidic platform for implementing molecular logic gate with fluorescent chemosensors",
abstract = "In this research, we report a micropump-actuated microfluidic device based on pneumatically-controlled valves implement molecular logic gates of fluorescent chemosensors which shows different intensities responding to different pH and ion conditions. The polydimethylsiloxane (PDMS) microfluidic device was fabricated by multilayer soft lithography. Logic mixing is achieved in a circulating loop by a pneumatic rotary micropump connected to a computer running LABVIEW program. The loop diameter is 1.6 mm and the channel dimensions are 100 µm wide by 10 µm high. This microfluidic system provides fixed-volume control and five chambers for two-factor logic gate conditioned mixing and efficient chemistry reactions on chip to obtain molecular logic gate of these fluorescent chemosensors. As results, INH and NOR two-input logic gates were attained after logic mixing on chip following changes in the intensity of fluorescent chemosensors. An integrated OR logic gate was achieved with two chemosensors which can behave separately XOR and AND logic gates. We also applied transferrin, a copper-binding protein, to copper chemosensor logic mixing and implemented a biological NOT(INH) logic gate. These results show that molecular logic gates which have been known to work only in solution can be implemented in an electronically controlled microfluidic device. This also suggests that our molecular logic gate platform will be further utilized in developing a wet microprocessor in the future.",
keywords = "Chemosensor, Microfluidics, Molecular logic gate, Transferrin",
author = "Songzi Kou and Nam, {Seong Won} and Juyoung Yoon and Sungsu Park",
note = "Funding Information: This research was equally supported by the NanoB/ ioscience & Technology Program (M10536090002-05N3609-00210) of the Ministry of Science and Technology (MOST), the SRC program of the Korea Science and Engineering Foundation (KOSEF) through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (Grant R11-2005-008-02003-0), and the Korean Research Foundation Grant (MOEHRD, Basic Research Promotion Fund) (KRF-2006-005-J04002). Funding Information: This research was equally supported by the Nano/Bioscience & Technology Program (M10536090002-05N3609-00210) of the Ministry of Science and Technology (MOST), the SRC program of the Korea Science and Engineering Foundation (KOSEF) through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (Grant R11-2005-008-02003-0), and the Korean Research Foundation Grant (MOEHRD, Basic Research Promotion Fund) (KRF-2006- 005-J04002). Publisher Copyright: {\textcopyright} 2007 CBMS.; 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 ; Conference date: 07-10-2007 Through 11-10-2007",
year = "2007",
language = "English",
series = "Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007",
publisher = "Chemical and Biological Microsystems Society",
pages = "1525--1527",
editor = "Jean-Louis Viovy and Patrick Tabeling and Stephanie Descroix and Laurent Malaquin",
booktitle = "Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007",
}