A microfluidic model to study the metastatic cascade: From adhesion to migration

W. A. Velema, P. P.M.F.A. Mulder, L. P. Lee, E. Verpoorte

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper presents a microfluidic model for studying the sequential steps of the cancer extravasation process, in which cancer cells exit capillaries and enter organs. We demonstrate the functionality of this model by co-culturing and observing the adhesion of SK-Mel-28 (Malignant Melanoma) cells to a Human Umbilical Vein Endothelial Cell (HUVEC) monolayer, followed by their migration through this HUVEC layer into gelatin-filled microgaps.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages650-652
Number of pages3
StatePublished - 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume1

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Country/TerritoryNetherlands
CityGroningen
Period3/10/107/10/10

Keywords

  • 3-D co-culture
  • Adhesion
  • Endothelial cells
  • Metastatic cascade
  • Migration
  • Monolayer

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