Abstract
A mechanistic dichotomy of one-step versus stepwise pathways in hydride and hydrogen transfer reactions of NADH analogues is discussed including the relation between two pathways: a continuous change versus a discontinuous change of the mechanism. Examples of stepwise electron-proton-electron transfer through a charge transfer (CT) complex in hydride transfer from NADH analogues to hydride acceptors are presented including the detection and the reactivity of the intermediate, that is, radical cations of NADH analogues. The relation between stepwise versus one-step mechanisms of hydride and hydrogen transfer reaction of NADH analogues is also clarified by showing examples of the change of the mechanism including the borderline.
| Original language | English |
|---|---|
| Pages (from-to) | 886-896 |
| Number of pages | 11 |
| Journal | Journal of Physical Organic Chemistry |
| Volume | 21 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2008 |
Keywords
- Electron transfer
- Hydride transfer
- Hydrogen transfer
- Mechanistic dichotomy
- NADH analogue