A mathematical model for the regulation of tryptophan promoter

Tai Hyun Park

doi:10.1007/BF02697395

A mathematical model for the regulation of tryptophan promoter

Tai Hyun Park

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3β-indolea-crylic acid (IAA). A mathematical model is proposed for the regulation of the promoter by the manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a plateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree with the previous experimental investigation.

Original language	English
Pages (from-to)	282-289
Number of pages	8
Journal	Korean Journal of Chemical Engineering
Volume	11
Issue number	4
DOIs	https://doi.org/10.1007/BF02697395
State	Published - Oct 1994

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10.1007/BF02697395

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title = "A mathematical model for the regulation of tryptophan promoter",

abstract = "Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3β-indolea-crylic acid (IAA). A mathematical model is proposed for the regulation of the promoter by the manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a plateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree with the previous experimental investigation.",

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PY - 1994/10

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N2 - Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3β-indolea-crylic acid (IAA). A mathematical model is proposed for the regulation of the promoter by the manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a plateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree with the previous experimental investigation.

AB - Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3β-indolea-crylic acid (IAA). A mathematical model is proposed for the regulation of the promoter by the manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a plateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree with the previous experimental investigation.

UR - https://www.scopus.com/pages/publications/51249166440

U2 - 10.1007/BF02697395

DO - 10.1007/BF02697395

M3 - Article

AN - SCOPUS:51249166440

SN - 0256-1115

VL - 11

SP - 282

EP - 289

JO - Korean Journal of Chemical Engineering

JF - Korean Journal of Chemical Engineering

IS - 4

ER -

A mathematical model for the regulation of tryptophan promoter

Abstract

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