A mathematical model for the regulation of tryptophan promoter

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Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3β-indolea-crylic acid (IAA). A mathematical model is proposed for the regulation of the promoter by the manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a plateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree with the previous experimental investigation.

Original languageEnglish
Pages (from-to)282-289
Number of pages8
JournalKorean Journal of Chemical Engineering
Issue number4
StatePublished - Oct 1994


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