Abstract
Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3β-indolea-crylic acid (IAA). A mathematical model is proposed for the regulation of the promoter by the manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a plateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree with the previous experimental investigation.
Original language | English |
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Pages (from-to) | 282-289 |
Number of pages | 8 |
Journal | Korean Journal of Chemical Engineering |
Volume | 11 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1994 |