A histone H1-binding-aptide-based apoptosis imaging probe for monitoring tumor responses to cancer therapy

Yonghyun Lee, Sunghyun Kim, Daejin Kim, Sangyong Jon

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Here we report the feasibility of using a high-affinity histone H1-binding peptide as a potential molecular apoptosis imaging probe. The Cy5.5-labeled peptide showed high selectivity for drug-treated apoptotic tumors compared with non-apoptotic tumors in various in vivo settings, enabling detection of tumor responses to both docetaxel chemotherapy and Herceptin antibody therapy as early as 12 hours after treatment with a high signal-to-background ratio, even at extremely low doses.

Original languageEnglish
Pages (from-to)390-393
Number of pages4
JournalMedChemComm
Volume8
Issue number2
DOIs
StatePublished - 2017

Fingerprint

Dive into the research topics of 'A histone H1-binding-aptide-based apoptosis imaging probe for monitoring tumor responses to cancer therapy'. Together they form a unique fingerprint.

Cite this