A highly selective fluorescent probe for thiol bioimaging

Jean Bouffard; Youngmi Kim; Timothy M. Swager; Ralph Weissleder; Scott A. Hilderbrand

doi:10.1021/ol702539v

A highly selective fluorescent probe for thiol bioimaging

Jean Bouffard, Youngmi Kim, Timothy M. Swager, Ralph Weissleder, Scott A. Hilderbrand

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

262 Scopus citations

Abstract

A new fluorescent turn-on probe (3) for the selective sensing and bioimaging of thiols is reported. In aqueous buffer solutions at physiological pH, thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the red-emissive donor-acceptor fluorophore (4). The probe displays excellent immunity to interference from nitrogen and oxygen nucleophiles and the imaging of thiols in living cells is demonstrated.

Original language	English
Pages (from-to)	37-40
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	1
DOIs	https://doi.org/10.1021/ol702539v
State	Published - 3 Jan 2008

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title = "A highly selective fluorescent probe for thiol bioimaging",

abstract = "A new fluorescent turn-on probe (3) for the selective sensing and bioimaging of thiols is reported. In aqueous buffer solutions at physiological pH, thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the red-emissive donor-acceptor fluorophore (4). The probe displays excellent immunity to interference from nitrogen and oxygen nucleophiles and the imaging of thiols in living cells is demonstrated.",

author = "Jean Bouffard and Youngmi Kim and Swager, {Timothy M.} and Ralph Weissleder and Hilderbrand, {Scott A.}",

year = "2008",

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AU - Bouffard, Jean

AU - Kim, Youngmi

AU - Swager, Timothy M.

AU - Weissleder, Ralph

AU - Hilderbrand, Scott A.

PY - 2008/1/3

Y1 - 2008/1/3

N2 - A new fluorescent turn-on probe (3) for the selective sensing and bioimaging of thiols is reported. In aqueous buffer solutions at physiological pH, thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the red-emissive donor-acceptor fluorophore (4). The probe displays excellent immunity to interference from nitrogen and oxygen nucleophiles and the imaging of thiols in living cells is demonstrated.

AB - A new fluorescent turn-on probe (3) for the selective sensing and bioimaging of thiols is reported. In aqueous buffer solutions at physiological pH, thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the red-emissive donor-acceptor fluorophore (4). The probe displays excellent immunity to interference from nitrogen and oxygen nucleophiles and the imaging of thiols in living cells is demonstrated.

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SN - 1523-7060

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JO - Organic Letters

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A highly selective fluorescent probe for thiol bioimaging

Abstract

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