A fluorescence sensor for Zn2+ that also acts as a visible sensor for Co2+ and Cu2+

Eun Joo Song, Gyeong Jin Park, Jae Jun Lee, Suyeon Lee, Insup Noh, Youngmee Kim, Sung Jin Kim, Cheal Kim, Roger G. Harrison

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Monitoring Zn2+ levels in biological environments with fluorescent sensors is important. This paper gives the synthesis and properties of a new Zn2+ sensor based on quinoline and pyridylaminophenol. The sensor is selective for Zn2+ and remains fluorescent when bound to Zn2 even in the presence of other metal ions. Along with fluorescing when bound to Zn2+, the sensor becomes colored when Cu2+ or Co2+ is added to it. These two metal ions result in the sensor becoming yellow. The crystal structure of the Cu-sensor complex shows that all of the sensor's nitrogens are bound to the metal ion. In studies with living cells, the fluorescence intensity of the sensor correlates to the concentration of Zn2+.

Original languageEnglish
Pages (from-to)268-275
Number of pages8
JournalSensors and Actuators, B: Chemical
Volume213
DOIs
StatePublished - 5 Jul 2015

Keywords

  • Copper sensor
  • Visible cobalt
  • Zinc fluorescent sensor

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