A fatal spontaneous gas gangrene due to Clostridium perfringens during neutropenia of allogeneic stem cell transplantation: Case report and literature review

Hae Lim Lee; Sung Yeon Cho; Dong Gun Lee; Yumi Ko; Ji In Hyun; Bo Kyoung Kim; Jae Hyun Seo; Jung Woo Lee; Seok Lee

doi:10.3947/ic.2014.46.3.199

A fatal spontaneous gas gangrene due to Clostridium perfringens during neutropenia of allogeneic stem cell transplantation: Case report and literature review

Hae Lim Lee
, Sung Yeon Cho
, Dong Gun Lee
, Yumi Ko
, Ji In Hyun
, Bo Kyoung Kim
, Jae Hyun Seo
, Jung Woo Lee
, Seok Lee

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Most cases of gas gangrene caused by Clostridium species begin with trauma-related injuries but in rare cases, spontaneous gas gangrene (SGG) can occur when patients have conditions such as advanced malignancy, diabetes, or immunosuppression. Clostridium perfringens, a rare cause of SGG, exists as normal flora of skin and intestines of human. Adequate antibiotics with surgical debridement of infected tissue is the only curative therapeutic management. Mortality rate among adults is reported range of 67-100% and majority of deaths are occurred within 24 hours of onset. We experienced a case of SGG on the trunk, buttock and thigh in a neutropenic patient with acute lymphoblastic leukemia. His clinical course was rapid and fatal during pre-engraftment neutropenic period of allogeneic stem cell transplantation.

Original language	English
Pages (from-to)	199-203
Number of pages	5
Journal	Infection and Chemotherapy
Volume	46
Issue number	3
DOIs	https://doi.org/10.3947/ic.2014.46.3.199
State	Published - 2014

Bibliographical note

Publisher Copyright:
© 2014 by The Korean Society of Infectious Diseases | Korean Society for Chemotherapy.

Keywords

Clostridium perfringens
Gas gangrene
Neutropenia
Stem cell transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3947/ic.2014.46.3.199

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title = "A fatal spontaneous gas gangrene due to Clostridium perfringens during neutropenia of allogeneic stem cell transplantation: Case report and literature review",

abstract = "Most cases of gas gangrene caused by Clostridium species begin with trauma-related injuries but in rare cases, spontaneous gas gangrene (SGG) can occur when patients have conditions such as advanced malignancy, diabetes, or immunosuppression. Clostridium perfringens, a rare cause of SGG, exists as normal flora of skin and intestines of human. Adequate antibiotics with surgical debridement of infected tissue is the only curative therapeutic management. Mortality rate among adults is reported range of 67-100\% and majority of deaths are occurred within 24 hours of onset. We experienced a case of SGG on the trunk, buttock and thigh in a neutropenic patient with acute lymphoblastic leukemia. His clinical course was rapid and fatal during pre-engraftment neutropenic period of allogeneic stem cell transplantation.",

keywords = "Clostridium perfringens, Gas gangrene, Neutropenia, Stem cell transplantation",

author = "Lee, \{Hae Lim\} and Cho, \{Sung Yeon\} and Lee, \{Dong Gun\} and Yumi Ko and Hyun, \{Ji In\} and Kim, \{Bo Kyoung\} and Seo, \{Jae Hyun\} and Lee, \{Jung Woo\} and Seok Lee",

note = "Publisher Copyright: {\textcopyright} 2014 by The Korean Society of Infectious Diseases | Korean Society for Chemotherapy.",

year = "2014",

doi = "10.3947/ic.2014.46.3.199",

language = "English",

volume = "46",

pages = "199--203",

journal = "Infection and Chemotherapy",

issn = "2093-2340",

publisher = "Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS, Korean Society of Pediatric Infectious Diseases",

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}

TY - JOUR

T1 - A fatal spontaneous gas gangrene due to Clostridium perfringens during neutropenia of allogeneic stem cell transplantation

T2 - Case report and literature review

AU - Lee, Hae Lim

AU - Cho, Sung Yeon

AU - Lee, Dong Gun

AU - Ko, Yumi

AU - Hyun, Ji In

AU - Kim, Bo Kyoung

AU - Seo, Jae Hyun

AU - Lee, Jung Woo

AU - Lee, Seok

PY - 2014

Y1 - 2014

N2 - Most cases of gas gangrene caused by Clostridium species begin with trauma-related injuries but in rare cases, spontaneous gas gangrene (SGG) can occur when patients have conditions such as advanced malignancy, diabetes, or immunosuppression. Clostridium perfringens, a rare cause of SGG, exists as normal flora of skin and intestines of human. Adequate antibiotics with surgical debridement of infected tissue is the only curative therapeutic management. Mortality rate among adults is reported range of 67-100% and majority of deaths are occurred within 24 hours of onset. We experienced a case of SGG on the trunk, buttock and thigh in a neutropenic patient with acute lymphoblastic leukemia. His clinical course was rapid and fatal during pre-engraftment neutropenic period of allogeneic stem cell transplantation.

AB - Most cases of gas gangrene caused by Clostridium species begin with trauma-related injuries but in rare cases, spontaneous gas gangrene (SGG) can occur when patients have conditions such as advanced malignancy, diabetes, or immunosuppression. Clostridium perfringens, a rare cause of SGG, exists as normal flora of skin and intestines of human. Adequate antibiotics with surgical debridement of infected tissue is the only curative therapeutic management. Mortality rate among adults is reported range of 67-100% and majority of deaths are occurred within 24 hours of onset. We experienced a case of SGG on the trunk, buttock and thigh in a neutropenic patient with acute lymphoblastic leukemia. His clinical course was rapid and fatal during pre-engraftment neutropenic period of allogeneic stem cell transplantation.

KW - Clostridium perfringens

KW - Gas gangrene

KW - Neutropenia

KW - Stem cell transplantation

UR - https://www.scopus.com/pages/publications/84908025548

U2 - 10.3947/ic.2014.46.3.199

DO - 10.3947/ic.2014.46.3.199

M3 - Article

AN - SCOPUS:84908025548

SN - 2093-2340

VL - 46

SP - 199

EP - 203

JO - Infection and Chemotherapy

JF - Infection and Chemotherapy

IS - 3

ER -

A fatal spontaneous gas gangrene due to Clostridium perfringens during neutropenia of allogeneic stem cell transplantation: Case report and literature review

Abstract

Bibliographical note

Keywords

UN SDGs

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