@article{05d2526fe1f74d34a9cbb67c8a67b9ac,
title = "A Far-Red-Emitting Fluorescence Probe for Sensitive and Selective Detection of Peroxynitrite in Live Cells and Tissues",
abstract = "In this study, the far-red-emitting fluorescence probe 1, containing a rhodamine derivative and a hydrazide reactive group, was developed for peroxynitrite detection and imaging. This probe, which is cell permeable and shows high sensitivity and selectivity in fluorometric detection of peroxynitrite over other ROS/RNS, was successfully utilized to detect exogenous and endogenous peroxynitrite in HeLa and RAW 264.7 cells, respectively. More importantly, 1 can also be used to detect endogenous peroxynitrite generated in Pseudomonas aeruginosa (PAO1)-infected mouse bone marrow-derived neutrophils. We anticipate that the new probe will serve as a powerful molecular imaging tool in investigations of the role(s) played by peroxynitrite in a variety of physiological and pathological contexts. (Figure Presented).",
author = "Di Wu and Ryu, {Jae Chan} and Chung, {Youn Wook} and Dayoung Lee and Ryu, {Ji Hwan} and Yoon, {Joo Heon} and Juyoung Yoon",
note = "Funding Information: This research was supported by grants from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (no. 2012R1A3A2048814), Global Research Laboratory (GRL) Program of the National Research Foundation (NRF) funded by Ministry of Science, ICT, Future Planning (2016K1A1A2910779), and the Bio & Medical Technology Development Program of the NRF funded by the Ministry of Science, ICT & Future Planning (2016M3A9D5A01952415). Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = oct,
day = "17",
doi = "10.1021/acs.analchem.7b02707",
language = "English",
volume = "89",
pages = "10924--10931",
journal = "Analytical Chemistry",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "20",
}