A double blind, placebo-controlled, randomized clinical trial that breast milk derived-Lactobacillus gasseri BNR17 mitigated diarrhea-dominant irritable bowel syndrome

Suk Pyo Shin, Yoon Mi Choi, Won Hee Kim, Sung Pyo Hong, Jong Min Park, Joohee Kim, Oran Kwon, Eun Hyun Lee, Ki Baik Hahm

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The exact pathogenesis of diarrhea-dominant irritable bowel syndrome (IBS) is not known, but the abnormal microbiota of the gastrointestinal tract is considered to be one of the important contributing factors as in other gastrointestinal diseases such as inflammatory bowel disease, antibiotic-associated diarrhea, and colorectal cancer as well as systemic diseases. Though diverse trials of probiotics had been continued in the treatment of diarrhea-IBS, only a few proved by randomized clinical trial. To prove the efficacy of Lactobacillus gasseri BNR17 isolated from breast milk in patients with diarrhea-IBS, prospective, randomized, placebo controlled clinical trial was done including health related-quality of life analysis, colon transit time, and the changes of fecal micro biota. BNR17 significantly improved the symptoms of diarrhea compared to control group. Health related-QOL analysis showed significant improvement of abdominal pain, distension, disturbed daily life, and mean defecation frequency with BNR17. On comparative CTT before and after BNR17, 6 out of 24 subjects showed significant correction of rapid colon transit pattern, while only 2 out of 24 in placebo (p<0.01). Upon fecal microbiota analysis, BNR17 significantly increased B. fecalis, E. rectale, C. aerofaciens, F. prausnitzil and B. steroris. Conclusively, Lactobacillus gasseri BNR17 can be a potential probiotics to ameliorate diarrhea-IBS.

Original languageEnglish
Pages (from-to)179-186
Number of pages8
JournalJournal of Clinical Biochemistry and Nutrition
Volume62
Issue number2
DOIs
StatePublished - Mar 2018

Keywords

  • Colon transit time
  • Diarrhea-dominant IBS
  • IBS-QOL
  • Lactobacillus gasseri BNR17
  • Microbiota

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