A DNA strand-nicking principle of a higher plant, Caesalpinia sappan

Woongchon Mar, Hyun Tai Lee, Kang Hoon Je, Hye Young Choi, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood of Caesalpinia sappan L. (Leguminosae) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood of C. sappan was subjected to the bioassay-guided fractionation, which led to the isolation of a known compound, brazilin (1) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalArchives of Pharmacal Research
Volume26
Issue number2
DOIs
StatePublished - 28 Feb 2003

Keywords

  • Brazilin
  • Caesalpinia sappan
  • DNA strand-scission

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