A Copper(I)-Mediated Tandem Three-Component Synthesis of 5-Allyl-1,2,3-triazoles

Yoona Song, Soyun Lee, Palash Dutta, Jae Sang Ryu

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7 Scopus citations


A copper(I)-mediated tandem three-component reaction using alkynes, azides, allyl iodides, CuI and NaNH 2 is developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further converted into 1,2,3-triazole-fused tricyclic scaffolds. This method features an efficient one-pot cascade route using commercial alkynes and affords the corresponding 5-allyl-1,2,3-triazoles with high yields and good selectivity under mild reaction conditions.

Original languageEnglish
Pages (from-to)744-754
Number of pages11
JournalSynthesis (Germany)
Issue number5
StatePublished - 3 Mar 2020

Bibliographical note

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© 2020 Georg Thieme Verlag. All rights reserved.


  • 1,2,3-triazoles
  • click reactions
  • copper catalyst
  • multicomponent reactions
  • one-pot reactions


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