A convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils

Dae Kee Kim; Young Woo Kim; Jongsik Gam; Jinsoo Lim; Key H. Kim

doi:10.1016/0040-4039(95)01238-D

A convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils

Dae Kee Kim, Young Woo Kim, Jongsik Gam, Jinsoo Lim, Key H. Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A general and convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils via 1,5-dialkyl-6-(methylsulfonyl)uracils 1 and 1,5-dialkyl-6-(methylsulfinyl)-2-thiouracils 2, respectively, has been described. The compounds 1 and 2 were synthesized from ethyl 2-alkyl-3,3-di(methylthio)acrylates 3 in five steps in good yields.

Original language	English
Pages (from-to)	6257-6260
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	35
DOIs	https://doi.org/10.1016/0040-4039(95)01238-D
State	Published - 28 Aug 1995

Keywords

5-dialkyl-2-thiouracils
5-dialkyluracils
6-substituted 1

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10.1016/0040-4039(95)01238-D

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title = "A convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils",

abstract = "A general and convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils via 1,5-dialkyl-6-(methylsulfonyl)uracils 1 and 1,5-dialkyl-6-(methylsulfinyl)-2-thiouracils 2, respectively, has been described. The compounds 1 and 2 were synthesized from ethyl 2-alkyl-3,3-di(methylthio)acrylates 3 in five steps in good yields.",

keywords = "5-dialkyl-2-thiouracils, 5-dialkyluracils, 6-substituted 1",

author = "Kim, {Dae Kee} and Kim, {Young Woo} and Jongsik Gam and Jinsoo Lim and Kim, {Key H.}",

year = "1995",

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T1 - A convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils

AU - Kim, Dae Kee

AU - Kim, Young Woo

AU - Gam, Jongsik

AU - Lim, Jinsoo

AU - Kim, Key H.

PY - 1995/8/28

Y1 - 1995/8/28

N2 - A general and convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils via 1,5-dialkyl-6-(methylsulfonyl)uracils 1 and 1,5-dialkyl-6-(methylsulfinyl)-2-thiouracils 2, respectively, has been described. The compounds 1 and 2 were synthesized from ethyl 2-alkyl-3,3-di(methylthio)acrylates 3 in five steps in good yields.

AB - A general and convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils via 1,5-dialkyl-6-(methylsulfonyl)uracils 1 and 1,5-dialkyl-6-(methylsulfinyl)-2-thiouracils 2, respectively, has been described. The compounds 1 and 2 were synthesized from ethyl 2-alkyl-3,3-di(methylthio)acrylates 3 in five steps in good yields.

KW - 5-dialkyl-2-thiouracils

KW - 5-dialkyluracils

KW - 6-substituted 1

UR - http://www.scopus.com/inward/record.url?scp=0029114803&partnerID=8YFLogxK

U2 - 10.1016/0040-4039(95)01238-D

DO - 10.1016/0040-4039(95)01238-D

M3 - Article

AN - SCOPUS:0029114803

SN - 0040-4039

VL - 36

SP - 6257

EP - 6260

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 35

ER -

A convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils

Abstract

Keywords

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