Abstract
Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regioisomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis.
Original language | English |
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Pages (from-to) | 607-609 |
Number of pages | 3 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 57 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2009 |
Keywords
- Claisen rearrangement
- Licochalcone E
- Licochalcone F
- Retrochalcone