A comparison of the clinical outcomes of patients with invasive lobular carcinoma and invasive ductal carcinoma of the breast according to molecular subtype in a Korean population

Seung T. Lim, Jong H. Yu, Heung K. Park, Byung I. Moon, Byung K. Ko, Young J. Suh

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: To investigate the clinicopathological characteristics and the survival outcomes of invasive lobular carcinoma (ILC) patients compared to invasive ductal carcinoma (IDC) patients according to their molecular subtype.Methods: We compared the clinicopathological characteristics, breast cancer-specific survival (BCSS) and overall survival (OS) between patients with IDC (n = 14,547) and ILC (n = 528).Results: The ILC presented with a larger tumor size, more advanced cancer stage, increased rate of hormonal receptor positivity, human epidermal growth factor 2 (HER2) negativity and mastectomy than the IDC. The ILC patients more frequently presented with the luminal A subtype, whereas the IDC patients more frequently presented with the luminal B, HER2-overexpression, or triple negative subtype. The BCSS and OS were not significantly different between the IDC and ILC for each molecular subtype.Conclusions: Similar to IDC patients, molecular subtype should be considered when determining the prognosis and treatment regimen for ILC patients.

Original languageEnglish
Article number56
JournalWorld Journal of Surgical Oncology
Volume12
Issue number1
DOIs
StatePublished - 13 Mar 2014

Keywords

  • Breast cancer-specific survival
  • Invasive ductal carcinoma
  • Invasive lobular carcinoma
  • Molecular subtype
  • Overall survival

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