TY - JOUR
T1 - A comparative study of the antithrombotic effect through activated endothelium of garlic powder and tomato extracts using a rodent model of collagen and epinephrine induced thrombosis
AU - Kim, Leeseon
AU - Lim, Yeni
AU - Park, Soo yeon
AU - Kim, You Jin
AU - Kwon, Oran
AU - Lee, Jin Hee
AU - Shin, Jae Ho
AU - Yang, Yoon Kyoung
AU - Kim, Ji Yeon
N1 - Publisher Copyright:
© 2018, The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - In this study, garlic powder, tomato extract and a mixture of both were analyzed for anti-thrombotic effects using a collagen and epinephrine induced thrombosis model. Rats were randomly assigned to control, thrombosis induced control (COL/EP), garlic powder (G), tomato extract (T) and mixture of garlic powder and tomato extract (GT) groups. Test materials were administered for 7 days and thrombosis was induced by collagen and epinephrine injection. The results showed that G, T, and GT delayed activated partial thromboplastin time and reduced the expression of intracellular adhesion molecule-1 mRNA. Histological analysis of aorta and lung revealed that thrombosis was partially improved by G, T, and GT. Although there was no synergistic effect in GT compared to G and T treatment, this study showed that G, T, and GT have anti-thrombotic effect.
AB - In this study, garlic powder, tomato extract and a mixture of both were analyzed for anti-thrombotic effects using a collagen and epinephrine induced thrombosis model. Rats were randomly assigned to control, thrombosis induced control (COL/EP), garlic powder (G), tomato extract (T) and mixture of garlic powder and tomato extract (GT) groups. Test materials were administered for 7 days and thrombosis was induced by collagen and epinephrine injection. The results showed that G, T, and GT delayed activated partial thromboplastin time and reduced the expression of intracellular adhesion molecule-1 mRNA. Histological analysis of aorta and lung revealed that thrombosis was partially improved by G, T, and GT. Although there was no synergistic effect in GT compared to G and T treatment, this study showed that G, T, and GT have anti-thrombotic effect.
KW - Activate partial thromboplastin time
KW - Anti-thrombotic effect
KW - Garlic
KW - Intracellular adhesion molecule-1
KW - Mixture of garlic and tomato
KW - Tomato
UR - http://www.scopus.com/inward/record.url?scp=85053558638&partnerID=8YFLogxK
U2 - 10.1007/s10068-018-0469-z
DO - 10.1007/s10068-018-0469-z
M3 - Article
AN - SCOPUS:85053558638
SN - 1226-7708
VL - 27
SP - 1513
EP - 1518
JO - Food Science and Biotechnology
JF - Food Science and Biotechnology
IS - 5
ER -