A combined neural-oxygen sensing multi-channel electrode array

Michelle Khine, Jeffrey K. Thompson, Steven M. Bierer, Lee J. Altamirano, Ralph D. Freeman, Luke P. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations


We are developing a neural probe with integrated oxygen sensors to investigate the relationship between tissue oxygenation and neural activity within the brain. A quantitative understanding of this relationship at a submillimeter scale could enhance current non-invasive brain imaging techniques and extend their application in science and medicine. The neural probe is a microfabricated multichannel electrode array. Two of 16 recording sites of the array were converted to amperometric oxygen sensors by applying a polarization voltage relative to a reference electrode. The remaining electrode sites were used to record neural activity. In-vitro tests demonstrated a linear relationship between oxygen sensor current and dissolved oxygen. Preliminary in-vivo tests within the cat's visual cortex demonstrated stimulus induced oxygen responses similar to those obtained using a conventional single channel Clark-style oxygen sensor.

Original languageEnglish
Title of host publicationConference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering
EditorsLaura J. Wolf, Jodi L. Strock
PublisherIEEE Computer Society
Number of pages4
ISBN (Electronic)0780375793
StatePublished - 2003
Event1st International IEEE EMBS Conference on Neural Engineering - Capri Island, Italy
Duration: 20 Mar 200322 Mar 2003

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554


Conference1st International IEEE EMBS Conference on Neural Engineering
CityCapri Island

Bibliographical note

Publisher Copyright:
© 2003 IEEE.


  • Amperometric sensors
  • Biomedical electrodes
  • Biomedical imaging
  • Brain
  • In vitro
  • Polarization
  • Probes
  • Sensor arrays
  • Testing
  • Voltage


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