A combined neural-oxygen sensing multi-channel electrode array

Michelle Khine; Jeffrey K. Thompson; Steven M. Bierer; Lee J. Altamirano; Ralph D. Freeman; Luke P. Lee

doi:10.1109/CNE.2003.1196793

A combined neural-oxygen sensing multi-channel electrode array

Michelle Khine, Jeffrey K. Thompson, Steven M. Bierer, Lee J. Altamirano, Ralph D. Freeman, Luke P. Lee

Department of Chemistry & Nanoscience

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Abstract

We are developing a neural probe with integrated oxygen sensors to investigate the relationship between tissue oxygenation and neural activity within the brain. A quantitative understanding of this relationship at a submillimeter scale could enhance current non-invasive brain imaging techniques and extend their application in science and medicine. The neural probe is a microfabricated multichannel electrode array. Two of 16 recording sites of the array were converted to amperometric oxygen sensors by applying a polarization voltage relative to a reference electrode. The remaining electrode sites were used to record neural activity. In-vitro tests demonstrated a linear relationship between oxygen sensor current and dissolved oxygen. Preliminary in-vivo tests within the cat's visual cortex demonstrated stimulus induced oxygen responses similar to those obtained using a conventional single channel Clark-style oxygen sensor.

Original language	English
Title of host publication	Conference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering
Editors	Laura J. Wolf, Jodi L. Strock
Publisher	IEEE Computer Society
Pages	204-207
Number of pages	4
ISBN (Electronic)	0780375793
DOIs	https://doi.org/10.1109/CNE.2003.1196793
State	Published - 2003
Event	1st International IEEE EMBS Conference on Neural Engineering - Capri Island, Italy Duration: 20 Mar 2003 → 22 Mar 2003

Publication series

Name	International IEEE/EMBS Conference on Neural Engineering, NER
Volume	2003-January
ISSN (Print)	1948-3546
ISSN (Electronic)	1948-3554

Conference

Conference	1st International IEEE EMBS Conference on Neural Engineering
Country/Territory	Italy
City	Capri Island
Period	20/03/03 → 22/03/03

Bibliographical note

Publisher Copyright:
© 2003 IEEE.

Keywords

Amperometric sensors
Biomedical electrodes
Biomedical imaging
Brain
In vitro
Polarization
Probes
Sensor arrays
Testing
Voltage

Access to Document

10.1109/CNE.2003.1196793

Cite this

Khine, M., Thompson, J. K., Bierer, S. M., Altamirano, L. J., Freeman, R. D., & Lee, L. P. (2003). A combined neural-oxygen sensing multi-channel electrode array. In L. J. Wolf, & J. L. Strock (Eds.), Conference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering (pp. 204-207). Article 1196793 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2003-January). IEEE Computer Society. https://doi.org/10.1109/CNE.2003.1196793

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abstract = "We are developing a neural probe with integrated oxygen sensors to investigate the relationship between tissue oxygenation and neural activity within the brain. A quantitative understanding of this relationship at a submillimeter scale could enhance current non-invasive brain imaging techniques and extend their application in science and medicine. The neural probe is a microfabricated multichannel electrode array. Two of 16 recording sites of the array were converted to amperometric oxygen sensors by applying a polarization voltage relative to a reference electrode. The remaining electrode sites were used to record neural activity. In-vitro tests demonstrated a linear relationship between oxygen sensor current and dissolved oxygen. Preliminary in-vivo tests within the cat's visual cortex demonstrated stimulus induced oxygen responses similar to those obtained using a conventional single channel Clark-style oxygen sensor.",

keywords = "Amperometric sensors, Biomedical electrodes, Biomedical imaging, Brain, In vitro, Polarization, Probes, Sensor arrays, Testing, Voltage",

author = "Michelle Khine and Thompson, {Jeffrey K.} and Bierer, {Steven M.} and Altamirano, {Lee J.} and Freeman, {Ralph D.} and Lee, {Luke P.}",

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Khine, M, Thompson, JK, Bierer, SM, Altamirano, LJ, Freeman, RD & Lee, LP 2003, A combined neural-oxygen sensing multi-channel electrode array. in LJ Wolf & JL Strock (eds), Conference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering., 1196793, International IEEE/EMBS Conference on Neural Engineering, NER, vol. 2003-January, IEEE Computer Society, pp. 204-207, 1st International IEEE EMBS Conference on Neural Engineering, Capri Island, Italy, 20/03/03. https://doi.org/10.1109/CNE.2003.1196793

A combined neural-oxygen sensing multi-channel electrode array. / Khine, Michelle; Thompson, Jeffrey K.; Bierer, Steven M. et al.
Conference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering. ed. / Laura J. Wolf; Jodi L. Strock. IEEE Computer Society, 2003. p. 204-207 1196793 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2003-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Khine M, Thompson JK, Bierer SM, Altamirano LJ, Freeman RD, Lee LP. A combined neural-oxygen sensing multi-channel electrode array. In Wolf LJ, Strock JL, editors, Conference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering. IEEE Computer Society. 2003. p. 204-207. 1196793. (International IEEE/EMBS Conference on Neural Engineering, NER). doi: 10.1109/CNE.2003.1196793

A combined neural-oxygen sensing multi-channel electrode array

Abstract

Publication series

Conference

Bibliographical note

Keywords

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