@inproceedings{375b9c57060d43c2bae403550c4a7a27,
title = "A combined neural-oxygen sensing multi-channel electrode array",
abstract = "We are developing a neural probe with integrated oxygen sensors to investigate the relationship between tissue oxygenation and neural activity within the brain. A quantitative understanding of this relationship at a submillimeter scale could enhance current non-invasive brain imaging techniques and extend their application in science and medicine. The neural probe is a microfabricated multichannel electrode array. Two of 16 recording sites of the array were converted to amperometric oxygen sensors by applying a polarization voltage relative to a reference electrode. The remaining electrode sites were used to record neural activity. In-vitro tests demonstrated a linear relationship between oxygen sensor current and dissolved oxygen. Preliminary in-vivo tests within the cat's visual cortex demonstrated stimulus induced oxygen responses similar to those obtained using a conventional single channel Clark-style oxygen sensor.",
keywords = "Amperometric sensors, Biomedical electrodes, Biomedical imaging, Brain, In vitro, Polarization, Probes, Sensor arrays, Testing, Voltage",
author = "Michelle Khine and Thompson, {Jeffrey K.} and Bierer, {Steven M.} and Altamirano, {Lee J.} and Freeman, {Ralph D.} and Lee, {Luke P.}",
note = "Publisher Copyright: {\textcopyright} 2003 IEEE.; 1st International IEEE EMBS Conference on Neural Engineering ; Conference date: 20-03-2003 Through 22-03-2003",
year = "2003",
doi = "10.1109/CNE.2003.1196793",
language = "English",
series = "International IEEE/EMBS Conference on Neural Engineering, NER",
publisher = "IEEE Computer Society",
pages = "204--207",
editor = "Wolf, {Laura J.} and Strock, {Jodi L.}",
booktitle = "Conference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering",
}