A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

Sung Keun Park; Hyejin Chun; Jae Hong Ryoo; Sang Wha Lee; Hong Soo Lee; Kyung Won Shim; Choo Yon Cho; Dong Ryeol Ryu; Taeg Su Ko; Eugene Kim; Se Jin Park; Jai Hyung Park; Seok Jin Hong; Hyun Pyo Hong

doi:10.1016/j.cca.2015.03.043

A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

Sung Keun Park, Hyejin Chun, Jae Hong Ryoo, Sang Wha Lee, Hong Soo Lee, Kyung Won Shim, Choo Yon Cho, Dong Ryeol Ryu, Taeg Su Ko, Eugene Kim, Se Jin Park, Jai Hyung Park, Seok Jin Hong, Hyun Pyo Hong

Department of Family Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P<. 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (. P for linear trend. =. 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men.

Original language	English
Pages (from-to)	111-116
Number of pages	6
Journal	Clinica Chimica Acta
Volume	446
DOIs	https://doi.org/10.1016/j.cca.2015.03.043
State	Published - 5 Jun 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

HOMA-IR
Insulin resistance
Microalbuminuria

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10.1016/j.cca.2015.03.043

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title = "A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men",

abstract = "Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P<. 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (. P for linear trend. =. 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men.",

keywords = "HOMA-IR, Insulin resistance, Microalbuminuria",

author = "Park, {Sung Keun} and Hyejin Chun and Ryoo, {Jae Hong} and Lee, {Sang Wha} and Lee, {Hong Soo} and Shim, {Kyung Won} and Cho, {Choo Yon} and Ryu, {Dong Ryeol} and Ko, {Taeg Su} and Eugene Kim and Park, {Se Jin} and Park, {Jai Hyung} and Hong, {Seok Jin} and Hong, {Hyun Pyo}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

month = jun,

day = "5",

doi = "10.1016/j.cca.2015.03.043",

language = "English",

volume = "446",

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journal = "Clinica Chimica Acta",

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T1 - A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

AU - Park, Sung Keun

AU - Chun, Hyejin

AU - Ryoo, Jae Hong

AU - Lee, Sang Wha

AU - Lee, Hong Soo

AU - Shim, Kyung Won

AU - Cho, Choo Yon

AU - Ryu, Dong Ryeol

AU - Ko, Taeg Su

AU - Kim, Eugene

AU - Park, Se Jin

AU - Park, Jai Hyung

AU - Hong, Seok Jin

AU - Hong, Hyun Pyo

PY - 2015/6/5

Y1 - 2015/6/5

N2 - Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P<. 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (. P for linear trend. =. 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men.

AB - Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P<. 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (. P for linear trend. =. 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men.

KW - HOMA-IR

KW - Insulin resistance

KW - Microalbuminuria

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EP - 116

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

Abstract

Bibliographical note

Keywords

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