A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

Sung Keun Park, Hyejin Chun, Jae Hong Ryoo, Sang Wha Lee, Hong Soo Lee, Kyung Won Shim, Choo Yon Cho, Dong Ryeol Ryu, Taeg Su Ko, Eugene Kim, Se Jin Park, Jai Hyung Park, Seok Jin Hong, Hyun Pyo Hong

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4 Scopus citations


Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P<. 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (. P for linear trend. =. 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalClinica Chimica Acta
StatePublished - 5 Jun 2015

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© 2015 Elsevier B.V.


  • Insulin resistance
  • Microalbuminuria


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