@article{3c523062fc9a48d09cba17e0efb8f4b5,
title = "A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform",
abstract = "5-Hydroxy-2-phenyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one (compound 52) was found as a DNA non-intercalative topo II specific catalytic inhibitor by targeting its ATP-binding domain. Showing changes in interaction with Mg2+, it exhibited highly selective properties against the α-isoform with less toxicity, unlike other topo II poisons, such as etoposide.",
author = "Seojeong Park and Hwang, {Soo Yeon} and Jaeho Shin and Hyunji Jo and Younghwa Na and Youngjoo Kwon",
note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (2018R1A5A2025286 and 2018R1A2B2006115 to YKwon and 2015M2A2A7A03044831 to YNa). Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry.",
year = "2019",
doi = "10.1039/c9cc05524j",
language = "English",
volume = "55",
pages = "12857--12860",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "85",
}