A chiral ketone for enantioselective recognition of 1,2-amino alcohols

Raju Nandhakumar, Yong En Guo, Hyunjung Park, Lijun Tang, Wonwoo Nam, Kwan Mook Kim

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15 Scopus citations


A novel auxillary chiral ketone has been designed, synthesized, and used to enantioselectively recognize 1,2-amino alcohols. This work proves that the keto group can serve as a chiral recognition center by imine formation supported by resonance assisted hydrogen bonding (RAHB).

Original languageEnglish
Pages (from-to)6582-6585
Number of pages4
JournalTetrahedron Letters
Issue number37
StatePublished - 10 Sep 2007

Bibliographical note

Funding Information:
This research was supported by the Ministry of Science and Technology of Korea, through NRL and SRC program of MOST/KOSEF at Ewha Womans University (Grant: R11-2005-008-000000) and by the Korea Research Foundation Grant (KRF-2004-005-C00093).


  • 1,2-Amino alcohols
  • Chiral ketone
  • Enantioselective recognition
  • Imine bond


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