A novel auxillary chiral ketone has been designed, synthesized, and used to enantioselectively recognize 1,2-amino alcohols. This work proves that the keto group can serve as a chiral recognition center by imine formation supported by resonance assisted hydrogen bonding (RAHB).
Bibliographical noteFunding Information:
This research was supported by the Ministry of Science and Technology of Korea, through NRL and SRC program of MOST/KOSEF at Ewha Womans University (Grant: R11-2005-008-000000) and by the Korea Research Foundation Grant (KRF-2004-005-C00093).
- 1,2-Amino alcohols
- Chiral ketone
- Enantioselective recognition
- Imine bond