TY - JOUR
T1 - A case of rivastigmine toxicity caused by transdermal patch
AU - Lee, Duk Hee
AU - Choi, Yoon Hee
AU - Cho, Kwang Hyun
AU - Yun, Soon Young
AU - Lee, Hyung Min
PY - 2011/7
Y1 - 2011/7
N2 - Rivastigmine is a carbamate cholinesterase inhibitor used in the treatment of dementia. Toxicity is expected to resemble poisoning from other carbamates and organophosphates with features of both muscarinic (salivation, lacrimation, urination, defecation, miosis, bronchorrhea, and bradycardia) and nicotinic (muscle weakness, fasciculations, and paralysis) stimulation. We present a case of rivastigmine toxicity caused by transdermal patch. After removal of patches, the patient's symptoms and signs were spontaneous recovery without atropine and oxime therapy. Emergency physicians should be aware of the signs of increased nicotinic, muscarinic, and central nervous system effects (seizure), which are the same as with organophosphate and carbamate toxicities, and strongly consider carbamate cholinesterase inhibitor (rivastigmine) overdose.
AB - Rivastigmine is a carbamate cholinesterase inhibitor used in the treatment of dementia. Toxicity is expected to resemble poisoning from other carbamates and organophosphates with features of both muscarinic (salivation, lacrimation, urination, defecation, miosis, bronchorrhea, and bradycardia) and nicotinic (muscle weakness, fasciculations, and paralysis) stimulation. We present a case of rivastigmine toxicity caused by transdermal patch. After removal of patches, the patient's symptoms and signs were spontaneous recovery without atropine and oxime therapy. Emergency physicians should be aware of the signs of increased nicotinic, muscarinic, and central nervous system effects (seizure), which are the same as with organophosphate and carbamate toxicities, and strongly consider carbamate cholinesterase inhibitor (rivastigmine) overdose.
UR - http://www.scopus.com/inward/record.url?scp=79959429096&partnerID=8YFLogxK
U2 - 10.1016/j.ajem.2010.05.024
DO - 10.1016/j.ajem.2010.05.024
M3 - Article
C2 - 20708894
AN - SCOPUS:79959429096
SN - 0735-6757
VL - 29
SP - 695.e1-695.e2
JO - American Journal of Emergency Medicine
JF - American Journal of Emergency Medicine
IS - 6
ER -