A case of reactive plasmacytosis mimicking multiple myeloma in a patient with primary Sjögren's syndrome

Jisoo Lee, Ji Eun Chang, Young Joo Cho, Seop Han Woon

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9 Scopus citations

Abstract

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease with well-documented association of lymphoid malignancies during the progress of the disease. Although several types of malignancy and pseudomalignancy have been reported in pSS, low-grade non-Hodgkin's lymphomas are the most frequently observed. Reactive plasmacytosis mimicking myeloma is a very rare condition in association with pSS. We describe a 72-yr-old woman with pSS who presented with hypergammaglobulinemia, and extensive bone marrow and lymph node plasmacytosis, which mimicked multiple myeloma. In this patient, there was an abnormal differentiation of memory B cells to plasma cells in the peripheral blood suggesting underlying pathogenetic mechanism for this condition.

Original languageEnglish
Pages (from-to)506-508
Number of pages3
JournalJournal of Korean Medical Science
Volume20
Issue number3
DOIs
StatePublished - Jun 2005

Keywords

  • B Cell Differentiation
  • Plasma Cells
  • Plasmacytosis
  • Sjogren's Syndrome

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