A case of prothionamide induced hepatitis on patient with multi-drug resistant pulmonary tuberculosis

Jun Beom Park; Byung Hoon Park; Ji Young Son; Ji Ye Jung; Eun Young Kim; Ju Eun Lim; Sang Hoon Lee; Sang Kook Lee; Song Yee Kim; Wonjai Jung; Seungtaek Lim; Kyung Jong Lee; Young Ae Kang; Young Sam Kim; Se Kyu Kim; Joon Chang; Junjeong Choi; Moo Suk Park

doi:10.4046/trd.2011.70.3.251

A case of prothionamide induced hepatitis on patient with multi-drug resistant pulmonary tuberculosis

Jun Beom Park, Byung Hoon Park, Ji Young Son, Ji Ye Jung, Eun Young Kim, Ju Eun Lim, Sang Hoon Lee, Sang Kook Lee, Song Yee Kim, Wonjai Jung, Seungtaek Lim, Kyung Jong Lee, Young Ae Kang, Young Sam Kim, Se Kyu Kim, Joon Chang, Junjeong Choi, Moo Suk Park

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis. Copyright

Original language	English
Pages (from-to)	251-256
Number of pages	6
Journal	Tuberculosis and Respiratory Diseases
Volume	70
Issue number	3
DOIs	https://doi.org/10.4046/trd.2011.70.3.251
State	Published - Mar 2011

Keywords

Hepatitis
Prothionamide
Tuberculosis, multidrug-resistant

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Park, J. B., Park, B. H., Son, J. Y., Jung, J. Y., Kim, E. Y., Lim, J. E., Lee, S. H., Lee, S. K., Kim, S. Y., Jung, W., Lim, S., Lee, K. J., Kang, Y. A., Kim, Y. S., Kim, S. K., Chang, J., Choi, J., & Park, M. S. (2011). A case of prothionamide induced hepatitis on patient with multi-drug resistant pulmonary tuberculosis. Tuberculosis and Respiratory Diseases, 70(3), 251-256. https://doi.org/10.4046/trd.2011.70.3.251

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title = "A case of prothionamide induced hepatitis on patient with multi-drug resistant pulmonary tuberculosis",

abstract = "The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis. Copyright",

keywords = "Hepatitis, Prothionamide, Tuberculosis, multidrug-resistant",

author = "Park, {Jun Beom} and Park, {Byung Hoon} and Son, {Ji Young} and Jung, {Ji Ye} and Kim, {Eun Young} and Lim, {Ju Eun} and Lee, {Sang Hoon} and Lee, {Sang Kook} and Kim, {Song Yee} and Wonjai Jung and Seungtaek Lim and Lee, {Kyung Jong} and Kang, {Young Ae} and Kim, {Young Sam} and Kim, {Se Kyu} and Joon Chang and Junjeong Choi and Park, {Moo Suk}",

year = "2011",

month = mar,

doi = "10.4046/trd.2011.70.3.251",

language = "English",

volume = "70",

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Park, JB, Park, BH, Son, JY, Jung, JY, Kim, EY, Lim, JE, Lee, SH, Lee, SK, Kim, SY, Jung, W, Lim, S, Lee, KJ, Kang, YA, Kim, YS, Kim, SK, Chang, J, Choi, J & Park, MS 2011, 'A case of prothionamide induced hepatitis on patient with multi-drug resistant pulmonary tuberculosis', Tuberculosis and Respiratory Diseases, vol. 70, no. 3, pp. 251-256. https://doi.org/10.4046/trd.2011.70.3.251

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AU - Kim, Eun Young

AU - Lim, Ju Eun

AU - Lee, Sang Hoon

AU - Lee, Sang Kook

AU - Kim, Song Yee

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AU - Lim, Seungtaek

AU - Lee, Kyung Jong

AU - Kang, Young Ae

AU - Kim, Young Sam

AU - Kim, Se Kyu

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AU - Choi, Junjeong

AU - Park, Moo Suk

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N2 - The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis. Copyright

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A case of prothionamide induced hepatitis on patient with multi-drug resistant pulmonary tuberculosis

Abstract

Keywords

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