A case of prothionamide induced hepatitis on patient with multi-drug resistant pulmonary tuberculosis

Jun Beom Park, Byung Hoon Park, Ji Young Son, Ji Ye Jung, Eun Young Kim, Ju Eun Lim, Sang Hoon Lee, Sang Kook Lee, Song Yee Kim, Wonjai Jung, Seungtaek Lim, Kyung Jong Lee, Young Ae Kang, Young Sam Kim, Se Kyu Kim, Joon Chang, Junjeong Choi, Moo Suk Park

Research output: Contribution to journalArticlepeer-review


The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis. Copyright

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalTuberculosis and Respiratory Diseases
Issue number3
StatePublished - Mar 2011


  • Hepatitis
  • Prothionamide
  • Tuberculosis, multidrug-resistant


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