A case of hypertrophic osteoarthropathy associated with epithelioid hemangioendothelioma

Jin Hyun Kim, Eun Bong Lee, Sunyoung Kim, Hyoun Woo Kang, Jung Won Suh, Won Jae Yoon, Su Hwan Kim, Eun Ha Kang, Churl Hyun Im, Yeong Wook Song, Hyo Suk Lee

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12 Scopus citations


Epithelioid hemangioendothelioma is a rare vascular tumor, which occurs in the lung, liver, bone, and soft tissue. Hypertrophic osteoarthropathy is a syndrome characterized by subperiosteal new bone formation, joint effusion and clubbing, and may be associated with cyanotic heart disease, chronic pulmonary disease, liver disease, and other miscellaneous diseases. The activation of endothelium and platelets has been suggested to be involved in the development of hypertrophic osteoarthropathy. We report a rare case of hypertrophic osteoarthropathy, which developed in association with hepatic epithelioid hemangioendothelioma with pulmonary metastasis. We also discuss the role of vascular endothelial growth factor in its pathogenesis.

Original languageEnglish
Pages (from-to)484-486
Number of pages3
JournalJournal of Korean Medical Science
Issue number3
StatePublished - Jun 2004


  • Hemangioendothelioma, Epithelioid
  • Osteoarthropathy, Secondary Hypertrophic
  • Vascular Endothelial Growth Factor


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