A case of disseminated multidrug-resistant tuberculosis involving the brain

Eun Kyo Jung; Ji Young Chang; Yoon Pyo Lee; Min Kyung Chung; Eui Kyo Seo; Hea Soo Koo; Hee Jung Choi

doi:10.3947/ic.2016.48.1.41

A case of disseminated multidrug-resistant tuberculosis involving the brain

Eun Kyo Jung, Ji Young Chang, Yoon Pyo Lee, Min Kyung Chung, Eui Kyo Seo, Hea Soo Koo, Hee Jung Choi

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4 Scopus citations

Abstract

We report a case of a 23-year-old female immigrant from China who was diagnosed with multidrug-resistant tuberculosis affecting her lung and brain, resistant to the standard first-line therapeutics and streptomycin. She was treated with prothionamide, moxifloxacin, cycloserine, and kanamycin. However, her headache and brain lesion worsened. After the brain biopsy, the patient was confirmed with intracranial tuberculoma. Linezolid was added to intensify the treatment regimen, and steroid was added for the possibility of paradoxical response. Kanamycin was discontinued 6 months after initiation of the treatment; she was treated for 18 months with susceptible drugs and completely recovered. To our knowledge, this case is the first multidrug- resistant tuberculosis that disseminated to the brain in Korea.

Original language	English
Pages (from-to)	41-46
Number of pages	6
Journal	Infection and Chemotherapy
Volume	48
Issue number	1
DOIs	https://doi.org/10.3947/ic.2016.48.1.41
State	Published - 1 Mar 2016

Bibliographical note

Publisher Copyright:
©2016 by The Korean Society of Infectious Diseases.

Keywords

Central nervous system
Multidrug-resistant
Mycobacterium tuberculosis
Pulmonary
Tuberculosis
Tuberculosis
Tuberculosis

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abstract = "We report a case of a 23-year-old female immigrant from China who was diagnosed with multidrug-resistant tuberculosis affecting her lung and brain, resistant to the standard first-line therapeutics and streptomycin. She was treated with prothionamide, moxifloxacin, cycloserine, and kanamycin. However, her headache and brain lesion worsened. After the brain biopsy, the patient was confirmed with intracranial tuberculoma. Linezolid was added to intensify the treatment regimen, and steroid was added for the possibility of paradoxical response. Kanamycin was discontinued 6 months after initiation of the treatment; she was treated for 18 months with susceptible drugs and completely recovered. To our knowledge, this case is the first multidrug- resistant tuberculosis that disseminated to the brain in Korea.",

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AU - Koo, Hea Soo

AU - Choi, Hee Jung

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A case of disseminated multidrug-resistant tuberculosis involving the brain

Abstract

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Keywords

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