A brain L-type calcium channel α1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3

Hemin Chin; Christine A. Kozak; Hyung Lae Kim; Beverly Mock; O. Wesley McBride

doi:10.1016/0888-7543(91)90014-6

A brain L-type calcium channel α1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3

Hemin Chin, Christine A. Kozak, Hyung Lae Kim, Beverly Mock, O. Wesley McBride

Department of Biochemistry

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A rat brain cDNA probe was used to localize a gene encoding the α1 subunit of neuronal dihydropyridine-sensitive L-type calcium channels in the mouse and human genomes. Hybridization of the probe to Southern blots made with DNAs from a Chinese hamster × mouse somatic cell hybrid panel indicated that this gene maps to mouse chromosome 14 (Chr 14). Southern blot analysis of an intersubspecies cross demonstrated that the calcium channel α1 subunit gene, termed Cchl1a2, can be positioned 7.5 cM proximal to Np-1. Similarly, segregation among human X rodent somatic cell hybrids indicated that CCHL1A2 maps to human chromosome 3. These assignments are consistent with a region of linkage homology between human chromosome 3p and a proximal region of mouse Chr 14.

Original language	English
Pages (from-to)	914-919
Number of pages	6
Journal	Genomics
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/0888-7543(91)90014-6
State	Published - Dec 1991

Access to Document

10.1016/0888-7543(91)90014-6

Cite this

@article{5c6e63bc474c40a091e9de111e2cb32f,

title = "A brain L-type calcium channel α1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3",

abstract = "A rat brain cDNA probe was used to localize a gene encoding the α1 subunit of neuronal dihydropyridine-sensitive L-type calcium channels in the mouse and human genomes. Hybridization of the probe to Southern blots made with DNAs from a Chinese hamster × mouse somatic cell hybrid panel indicated that this gene maps to mouse chromosome 14 (Chr 14). Southern blot analysis of an intersubspecies cross demonstrated that the calcium channel α1 subunit gene, termed Cchl1a2, can be positioned 7.5 cM proximal to Np-1. Similarly, segregation among human X rodent somatic cell hybrids indicated that CCHL1A2 maps to human chromosome 3. These assignments are consistent with a region of linkage homology between human chromosome 3p and a proximal region of mouse Chr 14.",

author = "Hemin Chin and Kozak, {Christine A.} and Kim, {Hyung Lae} and Beverly Mock and McBride, {O. Wesley}",

year = "1991",

month = dec,

doi = "10.1016/0888-7543(91)90014-6",

language = "English",

volume = "11",

pages = "914--919",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "4",

}

TY - JOUR

T1 - A brain L-type calcium channel α1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3

AU - Chin, Hemin

AU - Kozak, Christine A.

AU - Kim, Hyung Lae

AU - Mock, Beverly

AU - McBride, O. Wesley

PY - 1991/12

Y1 - 1991/12

N2 - A rat brain cDNA probe was used to localize a gene encoding the α1 subunit of neuronal dihydropyridine-sensitive L-type calcium channels in the mouse and human genomes. Hybridization of the probe to Southern blots made with DNAs from a Chinese hamster × mouse somatic cell hybrid panel indicated that this gene maps to mouse chromosome 14 (Chr 14). Southern blot analysis of an intersubspecies cross demonstrated that the calcium channel α1 subunit gene, termed Cchl1a2, can be positioned 7.5 cM proximal to Np-1. Similarly, segregation among human X rodent somatic cell hybrids indicated that CCHL1A2 maps to human chromosome 3. These assignments are consistent with a region of linkage homology between human chromosome 3p and a proximal region of mouse Chr 14.

AB - A rat brain cDNA probe was used to localize a gene encoding the α1 subunit of neuronal dihydropyridine-sensitive L-type calcium channels in the mouse and human genomes. Hybridization of the probe to Southern blots made with DNAs from a Chinese hamster × mouse somatic cell hybrid panel indicated that this gene maps to mouse chromosome 14 (Chr 14). Southern blot analysis of an intersubspecies cross demonstrated that the calcium channel α1 subunit gene, termed Cchl1a2, can be positioned 7.5 cM proximal to Np-1. Similarly, segregation among human X rodent somatic cell hybrids indicated that CCHL1A2 maps to human chromosome 3. These assignments are consistent with a region of linkage homology between human chromosome 3p and a proximal region of mouse Chr 14.

UR - http://www.scopus.com/inward/record.url?scp=0026341754&partnerID=8YFLogxK

U2 - 10.1016/0888-7543(91)90014-6

DO - 10.1016/0888-7543(91)90014-6

M3 - Article

C2 - 1664412

AN - SCOPUS:0026341754

SN - 0888-7543

VL - 11

SP - 914

EP - 919

JO - Genomics

JF - Genomics

IS - 4

ER -

A brain L-type calcium channel α1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3

Abstract

Access to Document

Fingerprint

Cite this