A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria

Eunhye Lee; Xingshu Li; Juwon Oh; Nahyun Kwon; Gyoungmi Kim; Dongho Kim; Juyoung Yoon

doi:10.1039/d0sc01351j

A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria

Eunhye Lee, Xingshu Li, Juwon Oh, Nahyun Kwon, Gyoungmi Kim, Dongho Kim, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Most existing photosensitizers (e.g., porphyrins) are often aggregated in aqueous solution because of their large conjugated molecular structures. This aggregation usually results in a lack or low levels of reactive oxygen species (ROS) generation due to aggregation-caused quenching, which severely hampers the application of photosensitizers in photodynamic therapy (PDT). Herein, we make an interesting finding that a boronic acid-functionalized phthalocyanine (PcN4-BA) displays an uncommon phenomenon, an aggregation-enhanced photodynamic effect. The combination of the ability to form uniform nanostructured self-assemblies in water, highly efficient ROS generation and boronic acid-induced targeting give PcN4-BA excellent performances in antimicrobial PDT.

Original language	English
Pages (from-to)	5735-5739
Number of pages	5
Journal	Chemical Science
Volume	11
Issue number	22
DOIs	https://doi.org/10.1039/d0sc01351j
State	Published - 14 Jun 2020

Bibliographical note

Funding Information:
J. Y. is thankful for nancial support from the National Research Foundation of Korea (NRF), which is funded by the Korea government (MSIP) (No. 2012R1A3A2048814). D. K. is thankful for the Strategic Research (NRF-2016R1E1A1A01943379) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science.

Publisher Copyright:
© The Royal Society of Chemistry 2020.

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10.1039/d0sc01351j

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title = "A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria",

abstract = "Most existing photosensitizers (e.g., porphyrins) are often aggregated in aqueous solution because of their large conjugated molecular structures. This aggregation usually results in a lack or low levels of reactive oxygen species (ROS) generation due to aggregation-caused quenching, which severely hampers the application of photosensitizers in photodynamic therapy (PDT). Herein, we make an interesting finding that a boronic acid-functionalized phthalocyanine (PcN4-BA) displays an uncommon phenomenon, an aggregation-enhanced photodynamic effect. The combination of the ability to form uniform nanostructured self-assemblies in water, highly efficient ROS generation and boronic acid-induced targeting give PcN4-BA excellent performances in antimicrobial PDT.",

author = "Eunhye Lee and Xingshu Li and Juwon Oh and Nahyun Kwon and Gyoungmi Kim and Dongho Kim and Juyoung Yoon",

note = "Funding Information: J. Y. is thankful for nancial support from the National Research Foundation of Korea (NRF), which is funded by the Korea government (MSIP) (No. 2012R1A3A2048814). D. K. is thankful for the Strategic Research (NRF-2016R1E1A1A01943379) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020.",

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doi = "10.1039/d0sc01351j",

language = "English",

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AU - Lee, Eunhye

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AU - Oh, Juwon

AU - Kwon, Nahyun

AU - Kim, Gyoungmi

AU - Kim, Dongho

AU - Yoon, Juyoung

N1 - Funding Information: J. Y. is thankful for nancial support from the National Research Foundation of Korea (NRF), which is funded by the Korea government (MSIP) (No. 2012R1A3A2048814). D. K. is thankful for the Strategic Research (NRF-2016R1E1A1A01943379) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science. Publisher Copyright: © The Royal Society of Chemistry 2020.

PY - 2020/6/14

Y1 - 2020/6/14

N2 - Most existing photosensitizers (e.g., porphyrins) are often aggregated in aqueous solution because of their large conjugated molecular structures. This aggregation usually results in a lack or low levels of reactive oxygen species (ROS) generation due to aggregation-caused quenching, which severely hampers the application of photosensitizers in photodynamic therapy (PDT). Herein, we make an interesting finding that a boronic acid-functionalized phthalocyanine (PcN4-BA) displays an uncommon phenomenon, an aggregation-enhanced photodynamic effect. The combination of the ability to form uniform nanostructured self-assemblies in water, highly efficient ROS generation and boronic acid-induced targeting give PcN4-BA excellent performances in antimicrobial PDT.

AB - Most existing photosensitizers (e.g., porphyrins) are often aggregated in aqueous solution because of their large conjugated molecular structures. This aggregation usually results in a lack or low levels of reactive oxygen species (ROS) generation due to aggregation-caused quenching, which severely hampers the application of photosensitizers in photodynamic therapy (PDT). Herein, we make an interesting finding that a boronic acid-functionalized phthalocyanine (PcN4-BA) displays an uncommon phenomenon, an aggregation-enhanced photodynamic effect. The combination of the ability to form uniform nanostructured self-assemblies in water, highly efficient ROS generation and boronic acid-induced targeting give PcN4-BA excellent performances in antimicrobial PDT.

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JO - Chemical Science

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ER -

A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria

Abstract

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