7-(Substituted-phenyl)amino-5,8-quinazolinediones: Potent inhibitors of endothelium-dependent vasorelaxation

Chung Kyu Ryu; Keun Hwa Shin; Ji Hui Seo; Hwa Jung Kim

7-(Substituted-phenyl)amino-5,8-quinazolinediones: Potent inhibitors of endothelium-dependent vasorelaxation

Chung Kyu Ryu, Keun Hwa Shin, Ji Hui Seo, Hwa Jung Kim

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Abstract

7-(Substituted-phenyl)amino-5,8-quinazolinediones (4) were synthesized by the substitution of 7-methoxy-5,8-quinazolinedione (5) with arylamines. All synthesized 5,8-quinazolinediones 4 showed a potent and efficacious inhibitory effect on the acetylcholine (ACh)-induced vasorelaxation of rat aorta with the endothelium. The quinones, at a low concentration of 0.1 μM, reduced the maximal response with an increase of EC₅₀ values for ACh. The results indicate that quinones 4 are potent inhibitors of endothelium-dependent vasorelaxation.

Original language	English
Pages (from-to)	605-614
Number of pages	10
Journal	Medicinal Chemistry Research
Volume	10
Issue number	9
State	Published - 2001

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@article{ac894375d29843ecbb39e0083f3c8d16,

title = "7-(Substituted-phenyl)amino-5,8-quinazolinediones: Potent inhibitors of endothelium-dependent vasorelaxation",

abstract = "7-(Substituted-phenyl)amino-5,8-quinazolinediones (4) were synthesized by the substitution of 7-methoxy-5,8-quinazolinedione (5) with arylamines. All synthesized 5,8-quinazolinediones 4 showed a potent and efficacious inhibitory effect on the acetylcholine (ACh)-induced vasorelaxation of rat aorta with the endothelium. The quinones, at a low concentration of 0.1 μM, reduced the maximal response with an increase of EC50 values for ACh. The results indicate that quinones 4 are potent inhibitors of endothelium-dependent vasorelaxation.",

author = "Ryu, \{Chung Kyu\} and Shin, \{Keun Hwa\} and Seo, \{Ji Hui\} and Kim, \{Hwa Jung\}",

year = "2001",

language = "English",

volume = "10",

pages = "605--614",

journal = "Medicinal Chemistry Research",

issn = "1054-2523",

publisher = "Springer",

number = "9",

}

TY - JOUR

T1 - 7-(Substituted-phenyl)amino-5,8-quinazolinediones

T2 - Potent inhibitors of endothelium-dependent vasorelaxation

AU - Ryu, Chung Kyu

AU - Shin, Keun Hwa

AU - Seo, Ji Hui

AU - Kim, Hwa Jung

PY - 2001

Y1 - 2001

N2 - 7-(Substituted-phenyl)amino-5,8-quinazolinediones (4) were synthesized by the substitution of 7-methoxy-5,8-quinazolinedione (5) with arylamines. All synthesized 5,8-quinazolinediones 4 showed a potent and efficacious inhibitory effect on the acetylcholine (ACh)-induced vasorelaxation of rat aorta with the endothelium. The quinones, at a low concentration of 0.1 μM, reduced the maximal response with an increase of EC50 values for ACh. The results indicate that quinones 4 are potent inhibitors of endothelium-dependent vasorelaxation.

AB - 7-(Substituted-phenyl)amino-5,8-quinazolinediones (4) were synthesized by the substitution of 7-methoxy-5,8-quinazolinedione (5) with arylamines. All synthesized 5,8-quinazolinediones 4 showed a potent and efficacious inhibitory effect on the acetylcholine (ACh)-induced vasorelaxation of rat aorta with the endothelium. The quinones, at a low concentration of 0.1 μM, reduced the maximal response with an increase of EC50 values for ACh. The results indicate that quinones 4 are potent inhibitors of endothelium-dependent vasorelaxation.

UR - https://www.scopus.com/pages/publications/0035690245

M3 - Article

AN - SCOPUS:0035690245

SN - 1054-2523

VL - 10

SP - 605

EP - 614

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 9

ER -

7-(Substituted-phenyl)amino-5,8-quinazolinediones: Potent inhibitors of endothelium-dependent vasorelaxation

Abstract

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