6-Arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation

Chung Kyu Ryu; Sung Hee Jung; Joung Ah Lee; Hwa Jung Kim; Soo Hwan Lee; Jin Ho Chung

doi:10.1016/S0960-894X(99)00411-4

6-Arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation

Chung Kyu Ryu, Sung Hee Jung, Joung Ah Lee, Hwa Jung Kim, Soo Hwan Lee, Jin Ho Chung

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

6-Arylamino-5,8-quinolinediones 3 and 7-arylamino-5,8-isoquinolinediones 4 were synthesized as inhibitors of endothelium-dependent vasorelaxation. The quinones inhibited the vasorelaxation of rat aorta with the endothelium. Among them, the quinones 3a, 3b, 3f, 4b, 4d and 4g strongly inhibited the vasorelaxation.

Original language	English
Pages (from-to)	2469-2472
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	17
DOIs	https://doi.org/10.1016/S0960-894X(99)00411-4
State	Published - 6 Sep 1999

Access to Document

10.1016/S0960-894X(99)00411-4

Cite this

@article{c8070a6866e944a1824a3721b59db5b6,

title = "6-Arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation",

abstract = "6-Arylamino-5,8-quinolinediones 3 and 7-arylamino-5,8-isoquinolinediones 4 were synthesized as inhibitors of endothelium-dependent vasorelaxation. The quinones inhibited the vasorelaxation of rat aorta with the endothelium. Among them, the quinones 3a, 3b, 3f, 4b, 4d and 4g strongly inhibited the vasorelaxation.",

author = "Ryu, \{Chung Kyu\} and Jung, \{Sung Hee\} and Lee, \{Joung Ah\} and Kim, \{Hwa Jung\} and Lee, \{Soo Hwan\} and Chung, \{Jin Ho\}",

year = "1999",

month = sep,

day = "6",

doi = "10.1016/S0960-894X(99)00411-4",

language = "English",

volume = "9",

pages = "2469--2472",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "17",

}

TY - JOUR

T1 - 6-Arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation

AU - Ryu, Chung Kyu

AU - Jung, Sung Hee

AU - Lee, Joung Ah

AU - Kim, Hwa Jung

AU - Lee, Soo Hwan

AU - Chung, Jin Ho

PY - 1999/9/6

Y1 - 1999/9/6

N2 - 6-Arylamino-5,8-quinolinediones 3 and 7-arylamino-5,8-isoquinolinediones 4 were synthesized as inhibitors of endothelium-dependent vasorelaxation. The quinones inhibited the vasorelaxation of rat aorta with the endothelium. Among them, the quinones 3a, 3b, 3f, 4b, 4d and 4g strongly inhibited the vasorelaxation.

AB - 6-Arylamino-5,8-quinolinediones 3 and 7-arylamino-5,8-isoquinolinediones 4 were synthesized as inhibitors of endothelium-dependent vasorelaxation. The quinones inhibited the vasorelaxation of rat aorta with the endothelium. Among them, the quinones 3a, 3b, 3f, 4b, 4d and 4g strongly inhibited the vasorelaxation.

UR - https://www.scopus.com/pages/publications/0033530103

U2 - 10.1016/S0960-894X(99)00411-4

DO - 10.1016/S0960-894X(99)00411-4

M3 - Article

C2 - 10498190

AN - SCOPUS:0033530103

SN - 0960-894X

VL - 9

SP - 2469

EP - 2472

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 17

ER -