4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp.

Inho Yang, Jisoo Yoon, Dayoung Kim, Dongyup Hahn, Sang Jip Nam, William Fenical

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

HPLC–UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data.

Original languageEnglish
Pages (from-to)2322-2324
Number of pages3
JournalTetrahedron Letters
Volume58
Issue number24
DOIs
StatePublished - 2017

Keywords

  • 14-Membered macrolide
  • Kromycin derivative
  • Marine-derived Streptomyces sp.
  • Pikromycin aglycone

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