@article{e7c96b9635ce453d89a216d37ca09ce1,
title = "4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp.",
abstract = "HPLC–UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data.",
keywords = "14-Membered macrolide, Kromycin derivative, Marine-derived Streptomyces sp., Pikromycin aglycone",
author = "Inho Yang and Jisoo Yoon and Dayoung Kim and Dongyup Hahn and Nam, {Sang Jip} and William Fenical",
note = "Funding Information: The present study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (NRF-2014R1A1A1003492), and by the U.S. National Cancer Institute (NIH) under grant R37CA044848 and instrument grant 1 S10 OD0106400-01A1 (HR-LC?MS, both to W.F.). We thank Drs C. Moore and A. Rheingold for assistance with the crystallization and the acquisition of X-ray diffraction data. Funding Information: The present study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (NRF-2014R1A1A1003492), and by the U.S. National Cancer Institute (NIH) under grant R37CA044848 and instrument grant 1 S10 OD0106400-01A1 (HR-LC–MS, both to W.F.). We thank Drs C. Moore and A. Rheingold for assistance with the crystallization and the acquisition of X-ray diffraction data. Publisher Copyright: {\textcopyright} 2017",
year = "2017",
doi = "10.1016/j.tetlet.2017.03.088",
language = "English",
volume = "58",
pages = "2322--2324",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "24",
}