Modified nucleosides continue to hold their position as one of the most fruitful classes of therapeutic agents in drug discovery. One fairly recent modification involves bioisosteric introduction of selenium at the 4′-position of the sugar ring, with the aim of overcoming the drawbacks of previous-generation 4′-oxo-, 4′-carba-, and 4′-thionucleosides. This review highlights the development of new 4′-selenonucleosides, summarizing various synthetic strategies involved in several prime modifications on the 4-selenosugar moiety.
- Conformation analysis
- Medicinal chemistry