4′-Selenonucleosides as Next-Generation Nucleosides

Pramod K. Sahu, Siddhi D. Naik, Jinha Yu, Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Modified nucleosides continue to hold their position as one of the most fruitful classes of therapeutic agents in drug discovery. One fairly recent modification involves bioisosteric introduction of selenium at the 4′-position of the sugar ring, with the aim of overcoming the drawbacks of previous-generation 4′-oxo-, 4′-carba-, and 4′-thionucleosides. This review highlights the development of new 4′-selenonucleosides, summarizing various synthetic strategies involved in several prime modifications on the 4-selenosugar moiety.

Original languageEnglish
Pages (from-to)6115-6124
Number of pages10
JournalEuropean Journal of Organic Chemistry
Volume2015
Issue number28
DOIs
StatePublished - 1 Oct 2015

Keywords

  • Conformation analysis
  • Medicinal chemistry
  • Nucleosides
  • Selenium
  • Selenonucleosides

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