4′-Selenonucleosides as Next-Generation Nucleosides

Pramod K. Sahu; Siddhi D. Naik; Jinha Yu; Lak Shin Jeong

doi:10.1002/ejoc.201500429

4′-Selenonucleosides as Next-Generation Nucleosides

Pramod K. Sahu, Siddhi D. Naik, Jinha Yu, Lak Shin Jeong

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Modified nucleosides continue to hold their position as one of the most fruitful classes of therapeutic agents in drug discovery. One fairly recent modification involves bioisosteric introduction of selenium at the 4′-position of the sugar ring, with the aim of overcoming the drawbacks of previous-generation 4′-oxo-, 4′-carba-, and 4′-thionucleosides. This review highlights the development of new 4′-selenonucleosides, summarizing various synthetic strategies involved in several prime modifications on the 4-selenosugar moiety.

Original language	English
Pages (from-to)	6115-6124
Number of pages	10
Journal	European Journal of Organic Chemistry
Volume	2015
Issue number	28
DOIs	https://doi.org/10.1002/ejoc.201500429
State	Published - 1 Oct 2015

Bibliographical note

Publisher Copyright:
Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

Conformation analysis
Medicinal chemistry
Nucleosides
Selenium
Selenonucleosides

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10.1002/ejoc.201500429

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title = "4′-Selenonucleosides as Next-Generation Nucleosides",

abstract = "Modified nucleosides continue to hold their position as one of the most fruitful classes of therapeutic agents in drug discovery. One fairly recent modification involves bioisosteric introduction of selenium at the 4′-position of the sugar ring, with the aim of overcoming the drawbacks of previous-generation 4′-oxo-, 4′-carba-, and 4′-thionucleosides. This review highlights the development of new 4′-selenonucleosides, summarizing various synthetic strategies involved in several prime modifications on the 4-selenosugar moiety.",

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author = "Sahu, {Pramod K.} and Naik, {Siddhi D.} and Jinha Yu and Jeong, {Lak Shin}",

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AU - Sahu, Pramod K.

AU - Naik, Siddhi D.

AU - Yu, Jinha

AU - Jeong, Lak Shin

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Modified nucleosides continue to hold their position as one of the most fruitful classes of therapeutic agents in drug discovery. One fairly recent modification involves bioisosteric introduction of selenium at the 4′-position of the sugar ring, with the aim of overcoming the drawbacks of previous-generation 4′-oxo-, 4′-carba-, and 4′-thionucleosides. This review highlights the development of new 4′-selenonucleosides, summarizing various synthetic strategies involved in several prime modifications on the 4-selenosugar moiety.

AB - Modified nucleosides continue to hold their position as one of the most fruitful classes of therapeutic agents in drug discovery. One fairly recent modification involves bioisosteric introduction of selenium at the 4′-position of the sugar ring, with the aim of overcoming the drawbacks of previous-generation 4′-oxo-, 4′-carba-, and 4′-thionucleosides. This review highlights the development of new 4′-selenonucleosides, summarizing various synthetic strategies involved in several prime modifications on the 4-selenosugar moiety.

KW - Conformation analysis

KW - Medicinal chemistry

KW - Nucleosides

KW - Selenium

KW - Selenonucleosides

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DO - 10.1002/ejoc.201500429

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VL - 2015

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EP - 6124

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 28

ER -

4′-Selenonucleosides as Next-Generation Nucleosides

Abstract

Bibliographical note

Keywords

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