Abstract
Obesity is a global chronic disease linked to various diseases. Increased consumption of added sugars, especially in beverages, is a key contributor to the obesity epidemic. It is essential to reduce or replace sugar intake with low-calorie sweeteners. Here, a natural sweet protein, 3M-brazzein, was investigated as a possible sugar substitute. Mice were exposed to 3M-brazzein or 10% sucrose of equivalent sweetness, in drinking water to mimic human obesity development over 15 weeks. Consumption of 3M-brazzein in liquid form did not cause adiposity hypertrophy, resulting in 33.1 ± 0.4 g body weight and 0.90 ± 0.2 mm fat accumulation, which were 35.9 ± 0.7 g (p = 0.0094) and 1.53 ± 0.067 mm (p = 0.0031), respectively, for sucrose supplement. Additionally, 3M-brazzein did not disrupt glucose homeostasis or affect insulin resistance and inflammation. Due to its naturally low-calorie content, 3M-brazzein could also be a potential sugar substitute that reduces adiposity.
Original language | English |
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Pages (from-to) | 2183-2192 |
Number of pages | 10 |
Journal | Journal of Agricultural and Food Chemistry |
Volume | 68 |
Issue number | 7 |
DOIs | |
State | Published - 19 Feb 2020 |
Bibliographical note
Publisher Copyright:Copyright © 2020 American Chemical Society.
Keywords
- brazzein
- low-calorie sweetener
- metabolic disorder
- obesity
- sugar substitute