@article{fc051b9927724ca1a354454e66a0279e,
title = "2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study",
abstract = "For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed.",
keywords = "2,6-Dithienyl-4-furyl pyridine, Antitumor agents, Cytotoxicity, Docking study, Topoisomerase I and II inhibitor",
author = "Arjun Basnet and Pritam Thapa and Radha Karki and Hoyoung Choi and Choi, {Jae Hun} and Minho Yun and Jeong, {Byeong Seon} and Yurngdong Jahng and Younghwa Na and Cho, {Won Jea} and Youngjoo Kwon and Lee, {Chong Soon} and Lee, {Eung Seok}",
note = "Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) ( KRF-2008-313-E00762 ). ",
year = "2010",
month = jan,
day = "1",
doi = "10.1016/j.bmcl.2009.11.041",
language = "English",
volume = "20",
pages = "42--47",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd.",
number = "1",
}