2,3-Diarylpyran-4-ones: A new series of selective cyclooxygenase-2 inhibitors

Yung Hyup Joo, Jin Kwan Kim, Seon Hwa Kang, Min Soo Noh, Jun Yong Ha, Jin Kyu Choi, Kyung Min Lim, Shin Chung

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


A new series of cyclooxygenase-2 (COX-2) inhibitors with γ-pyrone as central scaffold unit has been synthesized and their biological activities were evaluated against cyclooxygenase inhibitory activity. The changes of physical properties of the molecules were performed according to the medicinal chemistry principles and moderate oral anti-inflammatory activity was obtained with this series of inhibitors.

Original languageEnglish
Pages (from-to)2195-2198
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number9
StatePublished - 3 May 2004


  • Benzopyran
  • Cyclooxygenase-2
  • Pyrone


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