2,3-Diarylpyran-4-ones: A new series of selective cyclooxygenase-2 inhibitors

Yung Hyup Joo; Jin Kwan Kim; Seon Hwa Kang; Min Soo Noh; Jun Yong Ha; Jin Kyu Choi; Kyung Min Lim; Shin Chung

doi:10.1016/j.bmcl.2004.02.028

2,3-Diarylpyran-4-ones: A new series of selective cyclooxygenase-2 inhibitors

Yung Hyup Joo, Jin Kwan Kim, Seon Hwa Kang, Min Soo Noh, Jun Yong Ha, Jin Kyu Choi, Kyung Min Lim, Shin Chung

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A new series of cyclooxygenase-2 (COX-2) inhibitors with γ-pyrone as central scaffold unit has been synthesized and their biological activities were evaluated against cyclooxygenase inhibitory activity. The changes of physical properties of the molecules were performed according to the medicinal chemistry principles and moderate oral anti-inflammatory activity was obtained with this series of inhibitors.

Original language	English
Pages (from-to)	2195-2198
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2004.02.028
State	Published - 3 May 2004

Keywords

Benzopyran
Cyclooxygenase-2
Pyrone

Access to Document

10.1016/j.bmcl.2004.02.028

Cite this

@article{1f5bf9bfa1ca48fa8565af651779c011,

title = "2,3-Diarylpyran-4-ones: A new series of selective cyclooxygenase-2 inhibitors",

abstract = "A new series of cyclooxygenase-2 (COX-2) inhibitors with γ-pyrone as central scaffold unit has been synthesized and their biological activities were evaluated against cyclooxygenase inhibitory activity. The changes of physical properties of the molecules were performed according to the medicinal chemistry principles and moderate oral anti-inflammatory activity was obtained with this series of inhibitors.",

keywords = "Benzopyran, Cyclooxygenase-2, Pyrone",

author = "Joo, {Yung Hyup} and Kim, {Jin Kwan} and Kang, {Seon Hwa} and Noh, {Min Soo} and Ha, {Jun Yong} and Choi, {Jin Kyu} and Lim, {Kyung Min} and Shin Chung",

year = "2004",

month = may,

day = "3",

doi = "10.1016/j.bmcl.2004.02.028",

language = "English",

volume = "14",

pages = "2195--2198",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "9",

}

TY - JOUR

T1 - 2,3-Diarylpyran-4-ones

T2 - A new series of selective cyclooxygenase-2 inhibitors

AU - Joo, Yung Hyup

AU - Kim, Jin Kwan

AU - Kang, Seon Hwa

AU - Noh, Min Soo

AU - Ha, Jun Yong

AU - Choi, Jin Kyu

AU - Lim, Kyung Min

AU - Chung, Shin

PY - 2004/5/3

Y1 - 2004/5/3

N2 - A new series of cyclooxygenase-2 (COX-2) inhibitors with γ-pyrone as central scaffold unit has been synthesized and their biological activities were evaluated against cyclooxygenase inhibitory activity. The changes of physical properties of the molecules were performed according to the medicinal chemistry principles and moderate oral anti-inflammatory activity was obtained with this series of inhibitors.

AB - A new series of cyclooxygenase-2 (COX-2) inhibitors with γ-pyrone as central scaffold unit has been synthesized and their biological activities were evaluated against cyclooxygenase inhibitory activity. The changes of physical properties of the molecules were performed according to the medicinal chemistry principles and moderate oral anti-inflammatory activity was obtained with this series of inhibitors.

KW - Benzopyran

KW - Cyclooxygenase-2

KW - Pyrone

UR - http://www.scopus.com/inward/record.url?scp=1842639615&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2004.02.028

DO - 10.1016/j.bmcl.2004.02.028

M3 - Article

C2 - 15081007

AN - SCOPUS:1842639615

SN - 0960-894X

VL - 14

SP - 2195

EP - 2198

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

2,3-Diarylpyran-4-ones: A new series of selective cyclooxygenase-2 inhibitors

Abstract

Keywords

Access to Document

Fingerprint

Cite this