2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

Yung Hyup Joo; Jin Kwan Kim; Seon Hwa Kang; Min Soo Noh; Jun Yong Ha; Jin Kyu Choi; Kyung Min Lim; Chang Hoon Lee; Shin Chung

doi:10.1016/S0960-894X(02)00952-6

2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

Yung Hyup Joo
, Jin Kwan Kim
, Seon Hwa Kang
, Min Soo Noh
, Jun Yong Ha
, Jin Kyu Choi
, Kyung Min Lim
, Chang Hoon Lee
, Shin Chung

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.

Original language	English
Pages (from-to)	413-417
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(02)00952-6
State	Published - Feb 2003

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title = "2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors",

abstract = "A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.",

author = "Joo, \{Yung Hyup\} and Kim, \{Jin Kwan\} and Kang, \{Seon Hwa\} and Noh, \{Min Soo\} and Ha, \{Jun Yong\} and Choi, \{Jin Kyu\} and Lim, \{Kyung Min\} and Lee, \{Chang Hoon\} and Shin Chung",

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language = "English",

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T1 - 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

AU - Joo, Yung Hyup

AU - Kim, Jin Kwan

AU - Kang, Seon Hwa

AU - Noh, Min Soo

AU - Ha, Jun Yong

AU - Choi, Jin Kyu

AU - Lim, Kyung Min

AU - Lee, Chang Hoon

AU - Chung, Shin

PY - 2003/2

Y1 - 2003/2

N2 - A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.

AB - A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.

UR - https://www.scopus.com/pages/publications/0037330939

U2 - 10.1016/S0960-894X(02)00952-6

DO - 10.1016/S0960-894X(02)00952-6

M3 - Article

C2 - 12565941

AN - SCOPUS:0037330939

SN - 0960-894X

VL - 13

SP - 413

EP - 417

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -

2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

Abstract

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