2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

Yung Hyup Joo; Jin Kwan Kim; Seon Hwa Kang; Min Soo Noh; Jun Yong Ha; Jin Kyu Choi; Kyung Min Lim; Chang Hoon Lee; Shin Chung

doi:10.1016/S0960-894X(02)00952-6

2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

Yung Hyup Joo, Jin Kwan Kim, Seon Hwa Kang, Min Soo Noh, Jun Yong Ha, Jin Kyu Choi, Kyung Min Lim, Chang Hoon Lee, Shin Chung

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.

Original language	English
Pages (from-to)	413-417
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(02)00952-6
State	Published - Feb 2003

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title = "2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors",

abstract = "A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.",

author = "Joo, {Yung Hyup} and Kim, {Jin Kwan} and Kang, {Seon Hwa} and Noh, {Min Soo} and Ha, {Jun Yong} and Choi, {Jin Kyu} and Lim, {Kyung Min} and Lee, {Chang Hoon} and Shin Chung",

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T1 - 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

AU - Joo, Yung Hyup

AU - Kim, Jin Kwan

AU - Kang, Seon Hwa

AU - Noh, Min Soo

AU - Ha, Jun Yong

AU - Choi, Jin Kyu

AU - Lim, Kyung Min

AU - Lee, Chang Hoon

AU - Chung, Shin

PY - 2003/2

Y1 - 2003/2

N2 - A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.

AB - A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.

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U2 - 10.1016/S0960-894X(02)00952-6

DO - 10.1016/S0960-894X(02)00952-6

M3 - Article

C2 - 12565941

AN - SCOPUS:0037330939

SN - 0960-894X

VL - 13

SP - 413

EP - 417

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -

2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

Abstract

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