2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

Yung Hyup Joo, Jin Kwan Kim, Seon Hwa Kang, Min Soo Noh, Jun Yong Ha, Jin Kyu Choi, Kyung Min Lim, Chang Hoon Lee, Shin Chung

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number3
DOIs
StatePublished - Feb 2003

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