2-Cys peroxiredoxin function in intracellular signal transduction: Therapeutic implications

Sang Won Kang, Sue Goo Rhee, Tong Shin Chang, Woojin Jeong, Min Hee Choi

Research output: Contribution to journalReview articlepeer-review

295 Scopus citations

Abstract

H2O2 is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H2O2 generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H2O2 reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H 2O2 signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.

Original languageEnglish
Pages (from-to)571-578
Number of pages8
JournalTrends in Molecular Medicine
Volume11
Issue number12
DOIs
StatePublished - Dec 2005

Bibliographical note

Funding Information:
The authors are supported by grants from the Functional Proteomics Center of the 21 st Century Frontier Research Program funded by the Ministry of Science and Technology of the Korean Government and, in part, from National R and D program for Cancer Control (to S.W.K.). We thank Jaesang Kim for critically reading the manuscript.

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