TY - JOUR
T1 - 2-Cys peroxiredoxin function in intracellular signal transduction
T2 - Therapeutic implications
AU - Kang, Sang Won
AU - Rhee, Sue Goo
AU - Chang, Tong Shin
AU - Jeong, Woojin
AU - Choi, Min Hee
N1 - Funding Information:
The authors are supported by grants from the Functional Proteomics Center of the 21 st Century Frontier Research Program funded by the Ministry of Science and Technology of the Korean Government and, in part, from National R and D program for Cancer Control (to S.W.K.). We thank Jaesang Kim for critically reading the manuscript.
PY - 2005/12
Y1 - 2005/12
N2 - H2O2 is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H2O2 generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H2O2 reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H 2O2 signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.
AB - H2O2 is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H2O2 generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H2O2 reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H 2O2 signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.
UR - http://www.scopus.com/inward/record.url?scp=28244495868&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2005.10.006
DO - 10.1016/j.molmed.2005.10.006
M3 - Review article
C2 - 16290020
AN - SCOPUS:28244495868
SN - 1471-4914
VL - 11
SP - 571
EP - 578
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 12
ER -