2-Cys peroxiredoxin function in intracellular signal transduction: Therapeutic implications

Sang Won Kang; Sue Goo Rhee; Tong Shin Chang; Woojin Jeong; Min Hee Choi

doi:10.1016/j.molmed.2005.10.006

2-Cys peroxiredoxin function in intracellular signal transduction: Therapeutic implications

Sang Won Kang, Sue Goo Rhee, Tong Shin Chang, Woojin Jeong, Min Hee Choi

Department of Life Science

Research output: Contribution to journal › Review article › peer-review

299 Scopus citations

Abstract

H₂O₂ is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H₂O₂ generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H₂O₂ reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H ₂O₂ signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.

Original language	English
Pages (from-to)	571-578
Number of pages	8
Journal	Trends in Molecular Medicine
Volume	11
Issue number	12
DOIs	https://doi.org/10.1016/j.molmed.2005.10.006
State	Published - Dec 2005

Bibliographical note

Funding Information:
The authors are supported by grants from the Functional Proteomics Center of the 21 st Century Frontier Research Program funded by the Ministry of Science and Technology of the Korean Government and, in part, from National R and D program for Cancer Control (to S.W.K.). We thank Jaesang Kim for critically reading the manuscript.

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title = "2-Cys peroxiredoxin function in intracellular signal transduction: Therapeutic implications",

abstract = "H2O2 is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H2O2 generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H2O2 reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H 2O2 signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.",

author = "Kang, {Sang Won} and Rhee, {Sue Goo} and Chang, {Tong Shin} and Woojin Jeong and Choi, {Min Hee}",

note = "Funding Information: The authors are supported by grants from the Functional Proteomics Center of the 21 st Century Frontier Research Program funded by the Ministry of Science and Technology of the Korean Government and, in part, from National R and D program for Cancer Control (to S.W.K.). We thank Jaesang Kim for critically reading the manuscript.",

year = "2005",

month = dec,

doi = "10.1016/j.molmed.2005.10.006",

language = "English",

volume = "11",

pages = "571--578",

journal = "Trends in Molecular Medicine",

issn = "1471-4914",

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T1 - 2-Cys peroxiredoxin function in intracellular signal transduction

T2 - Therapeutic implications

AU - Kang, Sang Won

AU - Rhee, Sue Goo

AU - Chang, Tong Shin

AU - Jeong, Woojin

AU - Choi, Min Hee

N1 - Funding Information: The authors are supported by grants from the Functional Proteomics Center of the 21 st Century Frontier Research Program funded by the Ministry of Science and Technology of the Korean Government and, in part, from National R and D program for Cancer Control (to S.W.K.). We thank Jaesang Kim for critically reading the manuscript.

PY - 2005/12

Y1 - 2005/12

N2 - H2O2 is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H2O2 generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H2O2 reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H 2O2 signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.

AB - H2O2 is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H2O2 generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H2O2 reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H 2O2 signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.

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DO - 10.1016/j.molmed.2005.10.006

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SN - 1471-4914

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EP - 578

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 12

ER -

2-Cys peroxiredoxin function in intracellular signal transduction: Therapeutic implications

Abstract

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