일 상급종합병원 혈액내과 환자의 카바페넴분해효소생성 장내세균목 위험 요인

Purpose: This study aimed to assess the prevalence and characteristics of carbapenemase-producing Enterobacterales (CPE) carriage among patients who were admitted to hematology units to identify risk factors for CPE carriage. Methods: This retrospective case-control study was carried out at a tertiary hospital, with a specific focus on adult patients (18 years of age or older) who were admitted to the hematology department. The cases comprised 73 patients with CPE, while the controls comprised 292 individuals matched randomly in a 1:4 ratio according to gender and age. A retrospective review of electronic medical records was conducted to collect data using a CPE acquisition risk factor questionnaire. Patient characteristics, drugs used, and the duration of use were compared between two groups using univariate analysis, and the risk factors associated with CPE were analyzed using multiple logistic regression analysis. Results: The research findings indicated a prevalence of CPE of 5.4%. The predominant strain identified was Klebsiella pneumoniae, and the primary genotype identified was New Delhi metallo-beta-lactamase (NDM). A history of surgery and use of penicillin-based antibiotics were identified as risk factors for CPE carriage. Conclusion: The results emphasize the importance of establishing specific criteria when proactively screening high-risk patients for CPE. Furthermore, these findings provide evidence for forecasting risk factors associated with CPE and devising efficacious preventive measures.