β-carboline alkaloids from a Korean tunicate Eudistoma sp.

Weihong Wang; Sang Jip Nam; Byoung Chan Lee; Heonjoong Kang

doi:10.1021/np070064o

β-carboline alkaloids from a Korean tunicate Eudistoma sp.

Weihong Wang, Sang Jip Nam, Byoung Chan Lee, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Seven new β-carboline-based metabolites, designated as eudistomins Y₁-Y₇ (1-7), were isolated from a tunicate of the genus Eudistoma collected near Tong-Yeong City, South Sea, Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the β-carboline nucleus at C-1. Eudistomins Y₁-Y₇ were evaluated for their antibacterial activity, and eudistomin Y₆ exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermis and Bacillus subtilis without cytotoxicity in the MTT assay at 100 μM.

Original language	English
Pages (from-to)	163-166
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Issue number	2
DOIs	https://doi.org/10.1021/np070064o
State	Published - Feb 2008

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title = "β-carboline alkaloids from a Korean tunicate Eudistoma sp.",

abstract = "Seven new β-carboline-based metabolites, designated as eudistomins Y1-Y7 (1-7), were isolated from a tunicate of the genus Eudistoma collected near Tong-Yeong City, South Sea, Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the β-carboline nucleus at C-1. Eudistomins Y1-Y7 were evaluated for their antibacterial activity, and eudistomin Y6 exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermis and Bacillus subtilis without cytotoxicity in the MTT assay at 100 μM.",

author = "Weihong Wang and Nam, \{Sang Jip\} and Lee, \{Byoung Chan\} and Heonjoong Kang",

year = "2008",

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volume = "71",

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journal = "Journal of Natural Products",

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T1 - β-carboline alkaloids from a Korean tunicate Eudistoma sp.

AU - Wang, Weihong

AU - Nam, Sang Jip

AU - Lee, Byoung Chan

AU - Kang, Heonjoong

PY - 2008/2

Y1 - 2008/2

N2 - Seven new β-carboline-based metabolites, designated as eudistomins Y1-Y7 (1-7), were isolated from a tunicate of the genus Eudistoma collected near Tong-Yeong City, South Sea, Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the β-carboline nucleus at C-1. Eudistomins Y1-Y7 were evaluated for their antibacterial activity, and eudistomin Y6 exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermis and Bacillus subtilis without cytotoxicity in the MTT assay at 100 μM.

AB - Seven new β-carboline-based metabolites, designated as eudistomins Y1-Y7 (1-7), were isolated from a tunicate of the genus Eudistoma collected near Tong-Yeong City, South Sea, Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the β-carboline nucleus at C-1. Eudistomins Y1-Y7 were evaluated for their antibacterial activity, and eudistomin Y6 exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermis and Bacillus subtilis without cytotoxicity in the MTT assay at 100 μM.

UR - https://www.scopus.com/pages/publications/40549100992

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VL - 71

SP - 163

EP - 166

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

β-carboline alkaloids from a Korean tunicate Eudistoma sp.

Abstract

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