Abstract
Seven new β-carboline-based metabolites, designated as eudistomins Y1-Y7 (1-7), were isolated from a tunicate of the genus Eudistoma collected near Tong-Yeong City, South Sea, Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the β-carboline nucleus at C-1. Eudistomins Y1-Y7 were evaluated for their antibacterial activity, and eudistomin Y6 exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermis and Bacillus subtilis without cytotoxicity in the MTT assay at 100 μM.
Original language | English |
---|---|
Pages (from-to) | 163-166 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 71 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2008 |