β-carboline alkaloids from a Korean tunicate Eudistoma sp.

Weihong Wang, Sang Jip Nam, Byoung Chan Lee, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Seven new β-carboline-based metabolites, designated as eudistomins Y1-Y7 (1-7), were isolated from a tunicate of the genus Eudistoma collected near Tong-Yeong City, South Sea, Korea. These new metabolites differ from previously isolated marine metabolites due to the presence of a benzoyl group attached to the β-carboline nucleus at C-1. Eudistomins Y1-Y7 were evaluated for their antibacterial activity, and eudistomin Y6 exhibited moderate antibacterial activity against Gram-positive bacteria Staphylococcus epidermis and Bacillus subtilis without cytotoxicity in the MTT assay at 100 μM.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalJournal of Natural Products
Volume71
Issue number2
DOIs
StatePublished - Feb 2008

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