Department of Molecular Medicine

2018

Administration of alpha_s1-casein hydrolysate increases sleep and modulates GABA_A receptor subunit expression

Yayeh, T., Leem, Y. H., Kim, K. M., Jung, J. C., Schwarz, J., Oh, K. W. & Oh, S., May 2018, In: Biomolecules and Therapeutics. 26, 3, p. 268-273 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: Involvement of NF-κB, Nrf2, and PPAR-γ signaling pathways

Lee, E. J., Park, J. S., Lee, Y. Y., Kim, D. Y., Kang, J. L. & Kim, H. S., 23 Nov 2018, In: Journal of Neuroinflammation. 15, 1, 326.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR-γ expression and activation in macrophages

Kim, M. J., Lee, Y. J., Yoon, Y. S., Kim, M., Choi, J. H., Kim, H. S. & Kang, J. L., May 2018, In: Journal of Leukocyte Biology. 103, 5, p. 885-895 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Double intratibial injection of human tonsil-derived mesenchymal stromal cells recovers postmenopausal osteoporotic bone mass

KIM, G., JIN, Y. M., YU, Y., KIM, H. Y., JO, S. A., PARK, Y. J., PARK, Y. S. & JO, I. N. H. O., Aug 2018, In: Cytotherapy. 20, 8, p. 1013-1027 15 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain

Shin, J. A., Kim, Y. A., Kim, H. W., Kim, H. S., Lee, K. E., Kang, J. L. & Park, E. M., 1 May 2018, In: Neuropharmacology. 133, p. 202-215 14 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-κB signaling pathways

Lee, M. J., Chang, B. J., Oh, S., Nah, S. Y. & Cho, I. H., Oct 2018, In: Journal of Ginseng Research. 42, 4, p. 436-446 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Multitarget effects of Korean Red Ginseng in animal model of Parkinson's disease: antiapoptosis, antioxidant, antiinflammation, and maintenance of blood–brain barrier integrity

Choi, J. H., Jang, M., Nah, S. Y., Oh, S. & Cho, I. H., Jul 2018, In: Journal of Ginseng Research. 42, 3, p. 379-388 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Multi-target protective effects of gintonin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-mediated model of parkinson's disease via lysophosphatidic acid receptors

Choi, J. H., Jang, M., Oh, S., Nah, S. Y. & Cho, I. H., 23 May 2018, In: Frontiers in Pharmacology. 9, MAY, 515.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux

Jeong, S. J., Kim, S., Park, J. G., Jung, I. H., Lee, M. N., Jeon, S., Kweon, H. Y., Yu, D. Y., Lee, S. H., Jang, Y., Kang, S. W., Han, K. H., Miller, Y. I., Park, Y. M., Cheong, C., Choi, J. H. & Oh, G. T., 2 Jan 2018, In: Autophagy. 14, 1, p. 120-133 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

Repression of adenosine triphosphate–binding cassette transporter ABCG2 by estrogen increases intracellular glutathione in brain endothelial cells following ischemic reperfusion injury

Shin, J. A., Jeong, S. I., Kim, H. W., Jang, G., Ryu, D. R., Ahn, Y. H., Choi, J. H., Choi, Y. H. & Park, E. M., Jun 2018, In: Neurobiology of Aging. 66, p. 138-148 11 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Sulforaphane rescues amyloid-β Peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages

Jhang, K. A., Park, J. S., Kim, H. S. & Chong, Y. H., 12 Mar 2018, In: Journal of Neuroinflammation. 15, 1, 75.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Sustained release of parathyroid hormone via in situ cross-linking gelatin hydrogels improves the therapeutic potential of tonsil-derived mesenchymal stem cells for hypoparathyroidism

Park, Y. S., Lee, Y., Jin, Y. M., Kim, G., Jung, S. C., Park, Y. J., Park, K. D. & Jo, I., Mar 2018, In: Journal of Tissue Engineering and Regenerative Medicine. 12, 3, p. e1747-e1756

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Tonsil-derived mesenchymal stem cell-embedded in situ crosslinkable gelatin hydrogel therapy recovers postmenopausal osteoporosis through bone regeneration

Kim, G., Park, Y. S., Lee, Y., Jin, Y. M., Choi, D. H., Ryu, K. H., Park, Y. J., Park, K. D. & Jo, I., Jul 2018, In: PLoS ONE. 13, 7, e0200111.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Urinary Exosomal and cell-free DNA Detects Somatic Mutation and Copy Number Alteration in Urothelial Carcinoma of Bladder

Lee, D. H., Yoon, H., Park, S., Kim, J. S., Ahn, Y. H., Kwon, K., Lee, D. & Kim, K. H., 1 Dec 2018, In: Scientific Reports. 8, 1, 14707.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

2017

A benzylideneacetophenone derivative induces apoptosis of radiation-resistant human breast cancer cells via oxidative stress

Park, J. E., Piao, M. J., Kang, K. A., Shilnikova, K., Hyun, Y. J., Oh, S. K., Jeong, Y. J., Chae, S. & Hyun, J. W., 2017, In: Biomolecules and Therapeutics. 25, 4, p. 404-410 7 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Ajoene restored behavioral patterns and liver glutathione level in morphine treated C57BL6 mice

Yun, J., Oliynyk, S., Lee, Y., Kim, J., Yun, K., Jeon, R., Ryu, J. H. & Oh, S., 1 Jan 2017, In: Archives of Pharmacal Research. 40, 1, p. 106-111 6 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Anti-inflammatory mechanism of galangin in lipopolysaccharide-stimulated microglia: Critical role of PPAR-γ signaling pathway

Choi, M. J., Lee, E. J., Park, J. S., Kim, S. N., Park, E. M. & Kim, H. S., 15 Nov 2017, In: Biochemical Pharmacology. 144, p. 120-131 12 p.

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation

Jeong, Y. H., Park, J. S., Kim, D. H., Kang, J. L. & Kim, H. S., 1 May 2017, In: Pharmacological Research. 119, p. 431-442 12 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Autophagy induction in the skeletal myogenic differentiation of human tonsil-derived mesenchymal stem cells

Park, S., Choi, Y., Namhee, J., Kim, J., Oh, S., Yu, Y., Ahn, J. H., Jo, I., Choi, B. O. & Jung, S. C., 2017, In: International Journal of Molecular Medicine. 39, 4, p. 831-840 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

BPA-toxicity via superoxide anion overload and a deficit in β-catenin signaling in human bone mesenchymal stem cells

Leem, Y. H., Oh, S., Kang, H. J., Kim, J. H., Yoon, J. & Chang, J. S., 1 Jan 2017, In: Environmental Toxicology. 32, 1, p. 344-352 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Chronic stress-induced dendritic reorganization and abundance of synaptosomal PKA-dependent CP-AMPA receptor in the basolateral amygdala in a mouse model of depression

Yi, E. S., Oh, S., Lee, J. K. & Leem, Y. H., 6 May 2017, In: Biochemical and Biophysical Research Communications. 486, 3, p. 671-678 8 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Concanavalin A Induces Cortical Neuron Apoptosis by Causing ROS Accumulation and Tyrosine Kinase Activation

Jang, S., Yayeh, T., Leem, Y. H., Park, E. M., Ito, Y. & Oh, S., 1 Dec 2017, In: Neurochemical Research. 42, 12, p. 3504-3514 11 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Effect of individual and district-level socioeconomic disparities on cognitive decline in community-dwelling elderly in Seoul

Kim, G. H., Lee, H. A., Park, H., Lee, D. Y., Jo, I., Choi, S. H., Choi, K. G. & Jeong, J. H., 1 Sep 2017, In: Journal of Korean Medical Science. 32, 9, p. 1508-1515 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11

Tan, X., Banerjee, P., Guo, H. F., Ireland, S., Pankova, D., Ahn, Y. H., Nikolaidis, I. M., Liu, X., Zhao, Y., Xue, Y., Burns, A. R., Roybal, J., Gibbons, D. L., Zal, T., Creighton, C. J., Ungar, D., Wang, Y. & Kurie, J. M., 3 Jan 2017, In: Journal of Clinical Investigation. 127, 1, p. 117-131 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

Galangin suppresses pro-inflammatory gene expression in polyinosinic-polycytidylic acid-stimulated microglial cells

Choi, M. J., Park, J. S., Park, J. E., Kim, H. S. & Kim, H. S., 2017, In: Biomolecules and Therapeutics. 25, 6, p. 641-647 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone

Kim, H. J., Kim, J. S., Oh, S. & Yoo, H. S., 1 Aug 2017, In: Digestive Diseases. 35, 5, p. 439-443 5 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

MKK4 activates non-canonical NFκB signaling by promoting NFκB2-p100 processing

Kim, J. S., Kim, E. J., Kim, H. S., Kurie, J. M. & Ahn, Y. H., 16 Sep 2017, In: Biochemical and Biophysical Research Communications. 491, 2, p. 337-342 6 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Practical synthesis of chalcone derivatives and their biological activities

Jung, J. C., Lee, Y., Min, D., Jung, M. & Oh, S., Nov 2017, In: Molecules. 22, 11, 1872.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Regulation of neuroinflammation by matrix metalloproteinase-8 inhibitor derivatives in activated microglia and astrocytes

Lee, E. J., Choi, M. J., Lee, G., Gaire, B. P., Choi, J. W. & Kim, H. S., 2017, In: Oncotarget. 8, 45, p. 78677-78690 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Resveratrol Ameliorates Tau Hyperphosphorylation at Ser396 Site and Oxidative Damage in Rat Hippocampal Slices Exposed to Vanadate: Implication of ERK1/2 and GSK-3β Signaling Cascades

Jhang, K. A., Park, J. S., Kim, H. S. & Chong, Y. H., 8 Nov 2017, In: Journal of Agricultural and Food Chemistry. 65, 44, p. 9626-9634 9 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Simvastatin treatment boosts benefits of apoptotic cell infusion in murine lung fibrosis

Lee, Y. J., Kim, M. J., Yoon, Y. S., Choi, Y. H., Kim, H. S. & Kang, J. L., 2017, In: Cell Death and Disease. 8, 6, e2860.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Suppression of lipopolysaccharide-induced neuroinflammation by morin via MAPK, PI3K/Akt, and PKA/HO-1 signaling pathway modulation

Jung, J. S., Choi, M. J., Lee, Y. Y., Moon, B. I., Park, J. S. & Kim, H. S., 18 Jan 2017, In: Journal of Agricultural and Food Chemistry. 65, 2, p. 373-382 10 p.

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide

Kim, J., Jeong, Y. H., Lee, E. J., Park, J. S., Seo, H. & Kim, H. S., 18 Nov 2017, In: Biochemical and Biophysical Research Communications. 493, 2, p. 879-886 8 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Telmisartan mitigates hyperglycemia-induced vascular inflammation by increasing GSK3β-Ser⁹ phosphorylation in endothelial cells and mouse aortas

Song, K. H., Bae, S. J., Chang, J., Park, J. H., Jo, I., Cho, K. W. & Cho, D. H., 30 Sep 2017, In: Biochemical and Biophysical Research Communications. 491, 4, p. 903-911 9 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Therapeutic potential of tonsil-derived mesenchymal stem cells in dextran sulfate sodium-induced experimental murine colitis

Yu, Y., Song, E. M., Lee, K. E., Joo, Y. H., Kim, S. E., Moon, C. M., Kim, H. Y., Jung, S. A. & Jo, I., Aug 2017, In: PLoS ONE. 12, 8, e0183141.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Thy-1⁺ Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis

Schliekelman, M. J., Creighton, C. J., Baird, B. N., Chen, Y., Banerjee, P., Bota-Rabassedas, N., Ahn, Y. H., Roybal, J. D., Chen, F., Zhang, Y., Mishra, D. K., Kim, M. P., Liu, X., Mino, B., Villalobos, P., Rodriguez-Canales, J., Behrens, C., Wistuba, I. I., Hanash, S. M. & Kurie, J. M., 1 Dec 2017, In: Scientific Reports. 7, 1, 6478.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

2016

Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia

Lee, Y. Y., Lee, E. J., Park, J. S., Jang, S. E., Kim, D. H. & Kim, H. S., 1 Jun 2016, In: Journal of Neuroimmune Pharmacology. 11, 2, p. 294-305 12 p.

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Anti-tumor activity of benzylideneacetophenone derivatives via proteasomal inhibition in prostate cancer cells

Lee, Y. H., Yun, J., Jung, J. C., Oh, S. & Jung, Y. S., May 2016, In: Pharmazie. 71, 5, p. 274-279 6 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Cancer-associated fibroblasts induce a collagen cross-link switch in tumor stroma

Pankova, D., Chen, Y., Terajima, M., Schliekelman, M. J., Baird, B. N., Fahrenholtz, M., Sun, L., Gill, B. J., Vadakkan, T. J., Kim, M. P., Ahn, Y. H., Roybal, J. D., Liu, X., Cuentas, E. R. P., Rodriguez, J., Wistuba, I. I., Creighton, C. J., Gibbons, D. L., Hicks, J. M. & Dickinson, M. E. & 5 others, West, J. L., Grande-Allen, K. J., Hanash, S. M., Yamauchi, M. & Kurie, J. M., Mar 2016, In: Molecular Cancer Research. 14, 3, p. 287-295 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

150 Scopus citations

Citron Rho-interacting kinase mediates arsenite-induced decrease in endothelial nitric oxide synthase activity by increasing phosphorylation at threonine 497: Mechanism underlying arsenite-induced vascular dysfunction

Seo, J., Cho, D. H., Lee, H. J., Sung, M. S., Lee, J. Y., Won, K. J., Park, J. H. & Jo, I., 1 Jan 2016, In: Free Radical Biology and Medicine. 90, p. 133-144 12 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Disruption of neuronal nitric oxide synthase dimerization contributes to the development of Alzheimer's disease: Involvement of cyclin-dependent kinase 5-mediated phosphorylation of neuronal nitric oxide synthase at Ser²⁹³

Kwon, K. J., Park, J. H., Jo, I., Song, K. H., Han, J. S., Park, S. H., Han, S. H. & Cho, D. H., 1 Oct 2016, In: Neurochemistry International. 99, p. 52-61 10 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Exogenous C2 ceramide suppresses matrix metalloproteinase gene expression by inhibiting ROS production and MAPK signaling pathways in PMA-stimulated human astroglioma cells

Jung, J. S., Ahn, Y. H., Moon, B. I. & Kim, H. S., 31 Mar 2016, In: International Journal of Molecular Sciences. 17, 4, 477.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Expression of angiopoietin-1 in hypoxic pericytes: Regulation by hypoxia-inducible factor-2α and participation in endothelial cell migration and tube formation

Park, Y. S., Kim, G., Jin, Y. M., Lee, J. Y., Shin, J. W. & Jo, I., 8 Jan 2016, In: Biochemical and Biophysical Research Communications. 469, 2, p. 263-269 7 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Expression of tenocyte lineage-related factors from tonsil-derived mesenchymal stem cells

Yu, Y., Lee, S. Y., Yang, E. J., Kim, H. Y., Jo, I. & Shin, S. J., 1 Apr 2016, In: Tissue Engineering and Regenerative Medicine. 13, 2, p. 162-170 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression

Chen, L., Yi, X., Goswami, S., Ahn, Y. H., Roybal, J. D., Yang, Y., Diao, L., Peng, D., Peng, D., Fradette, J. J., Wang, J., Byers, L. A., Kurie, J. M., Ullrich, S. E., Qin, F. X. F. & Gibbons, D. L., 1 Nov 2016, In: OncoImmunology. 5, 11, e1234570.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease

Jung, J. C., Lee, Y. H., Kim, S. H., Kim, K. J., Kim, K. M., Oh, S. & Jung, Y. S., 22 Jan 2016, In: BMC Complementary and Alternative Medicine. 16, 1, 19.

Research output: Contribution to journal › Article › peer-review

Open Access

89 Scopus citations

Inhibition of p38 pathway-dependent MPTP-induced dopaminergic neurodegeneration in estrogen receptor alpha knockout mice

Hwang, C. J., Choi, D. Y., Jung, Y. Y., Lee, Y. J., Yun, J. S., Oh, K. W., Han, S. B., Oh, S., Park, M. H. & Hong, J. T., 1 Apr 2016, In: Hormones and Behavior. 80, p. 19-29 11 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

K_Ca3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress

Choi, S., Kim, J. A., Li, H. Y., Shin, K. O., Oh, G. T., Lee, Y. M., Oh, S., Pewzner-Jung, Y., Futerman, A. H. & Suh, S. H., 1 Oct 2016, In: Aging Cell. 15, 5, p. 801-810 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Korean Red Ginseng and Ginsenoside-Rb1/-Rg1 Alleviate Experimental Autoimmune Encephalomyelitis by Suppressing Th1 and Th17 Cells and Upregulating Regulatory T Cells

Lee, M. J., Jang, M., Choi, J., Chang, B. S., Kim, D. Y., Kim, S. H., Kwak, Y. S., Oh, S., Lee, J. H., Chang, B. J., Nah, S. Y. & Cho, I. H., 1 Apr 2016, In: Molecular Neurobiology. 53, 3, p. 1977-2002 26 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages

Kim, S. Y., Lim, E. J., Yoon, Y. S., Ahn, Y. H., Park, E. M., Kim, H. S. & Kang, J. L., 13 Jul 2016, In: Scientific Reports. 6, 29673.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Department of Molecular Medicine

Research output

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